The vitamin D status of the US population from 1988 to 2010 using standardized serum concentrations of 25-hydroxyvitamin D shows recent modest increases
The vitamin D status of the US population from 1988 to 2010 using standardized serum concentrations of 25-hydroxyvitamin D shows recent modest increases
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DOI：
10.3945/ajcn.115.127985
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发表时间：
2016-08-01
影响因子：
7.1
通讯作者：
Johnson, Clifford L.
中科院分区：
文献类型：
--
作者：
Schleicher, Rosemary L.;Sternberg, Maya R.;Johnson, Clifford L.
背景：由于血清25-羟基维生素D [25(OH)D]测量未标准化，美国人群维生素D状态的时间趋势一直不确定。目的：为了准确评估bb0 = 12岁人群中维生素D状况的趋势，我们使用了来自横断面NHANESs的数据。设计：采用液相色谱-串联质谱（LC-MS/MS）测量25(OH)D（25-羟基维生素D2和25-羟基维生素D-3的总和）的方法，校准为标准参比物质，用于预测放射免疫测定数据的LC-MS/MS当量浓度（1988-2006年调查，n = 38,700）和LC-MS/MS浓度（2007-2010年调查，n = 12,446）。计算加权算术平均值和25(OH)D高于或低于临界值浓度的患病率，以评估长期趋势。结果：1988 ~ 2006年25(OH)D的预测值平均值无时间变化趋势，但2007 ~ 2010年25(OH)D的预测值平均值升高了5 ~ 6 nmol/L。25(OH)D增加最多（7-11 nmol/L）的人群是老年人、女性、非西班牙裔白人和维生素D补充剂使用者。在1988 - 2010年期间，25(OH)D，40 nmol/L的人群比例为14-18%（总体），46-60%（非西班牙裔黑人），21-28%（墨西哥裔美国人）和6-10%（非西班牙裔白人）。结论：测量25(OH)D的精确方法显示，在美国人群中25(OH)D的平均浓度稳定（1988-2006），最近略有增加（2007-2010）。虽然目前还不清楚与不同的实验室方法相比，补充剂的使用在多大程度上解释了25(OH)D的增加，但使用较高的维生素D补充剂剂量与这种增加相吻合。25(OH)D浓度的种族差异明显。这些数据首次提供了有关美国人口维生素D水平时间趋势的标准化信息。
Background: Temporal trends in the US population's vitamin D status have been uncertain because of nonstandardized serum 25-hydroxyvitamin D [25(OH)D] measurements.Objective: To accurately assess vitamin D status trends among those aged >= 12 y, we used data from the cross-sectional NHANESs.Design: A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for measuring 25(OH)D (sum of 25-hydroxyvitamin D2 and 25-hydroxyvitamin D-3), calibrated to standard reference materials, was used to predict LC-MS/MS-equivalent concentrations from radioimmunoassay data (1988-2006 surveys; n = 38,700) and to measure LC-MS/MS concentrations (2007-2010 surveys; n = 12,446). Weighted arithmetic means and the prevalence of 25(OH)D above or below cutoff concentrations were calculated to evaluate long-term trends.Results: Overall, mean predicted 25(OH)D showed no time trend from 1988 to 2006, but during 2007-2010 the mean measured 25(OH)D was 5-6 nmol/L higher. Those groups who showed the largest 25(OH)D increases (7-11 nmol/L) were older, female, non-Hispanic white, and vitamin D supplement users. During 19882010, the proportions of persons with 25(OH)D,40 nmol/L were 14-18% (overall), 46-60% (non-Hispanic blacks), 21-28% (Mexican Americans), and 6-10% (non-Hispanic whites).Conclusions: An accurate method for measuring 25(OH)D showed stable mean concentrations in the US population (1988-2006) and recent modest increases (2007-2010). Although it is unclear to what extent supplement usage compared with different laboratory methods explain the increases in 25(OH)D, the use of higher vitamin D supplement dosages coincided with the increase. Marked race-ethnic differences in 25(OH)D concentrations were apparent. These data provide the first standardized information about temporal trends in the vitamin D status of the US population.