Demographic Differences in Willingness to Provide Broad and Narrow Consent for Biobank Research
Demographic Differences in Willingness to Provide Broad and Narrow Consent for Biobank Research
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DOI：
10.1089/bio.2014.0032
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发表时间：
2015-04-01
影响因子：
1.6
通讯作者：
Kaufman, David
中科院分区：
文献类型：
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作者：
Ewing, Altovise T.;Erby, Lori A. H.;Kaufman, David
目的：本研究检查了两个生物库同意模型的可接受性，并评估了对隐私和遗传保护措施的信念对acceptance.Methods的影响：美国成年人在英语和西班牙语在线调查中被随机分配到两个场景之一，检查接受广泛同意（n=1528）或狭窄同意（n=1533）。总体而言，提供广泛（76%）和狭义（74%）同意的意愿相似。非裔美国人与非西班牙裔白色人一样可能接受狭义同意（72% vs. 77%，p=0.35），但接受广义同意的可能性明显较低（69% vs. 81%，p=0.004）。教育，保险和献血史也与接受有关。调整有关隐私和政策保护的信念（遗传信息非歧视法，GINA），变量的影响减少。从GINA中得到安慰的受访者更有可能支持双方的同意（两者都是p
Purpose: This study examined acceptability of two biobank consent models and evaluated the impact of beliefs about privacy and genetic safeguards on acceptance.Methods: U.S. adults surveyed online in English and Spanish were randomly assigned to one of two scenarios examining acceptance of broad consent (n=1528), or narrow consent (n=1533).Results: Overall, willingness to provide broad (76%) and narrow (74%) consents were similar. African Americans were as likely as white non-Hispanics to accept narrow consent (72% vs. 77%, p=0.35) but significantly less likely to accept broad consent (69% vs. 81%, p=0.004). Education, insurance, and blood donation history were also related to acceptance. Adjusting for beliefs about privacy and policy protections (Genetic Information Nondiscrimination Act, GINA), the effects of the variables were reduced. Respondents who drew comfort from GINA were more likely to support both consent (both p