'Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration
'Standard THC units': a proposal to standardize dose across all cannabis products and methods of administration
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DOI：
10.1111/add.14842
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发表时间：
2019-12-09
期刊：
影响因子：
6
通讯作者：
Lorenzetti, Valentina
中科院分区：
文献类型：
--
作者：
Freeman, Tom P.;Lorenzetti, Valentina
大麻产品正变得越来越多样化，并且在增量（9）-四氢大麻酚（THC）和大麻二酚（CBD）的浓度方面变化很大。更高剂量的THC会增加大麻危害的风险，而CBD可能会部分抵消其中的一些影响。低风险大麻使用指南目前缺乏基于使用量的建议，可以通过实施标准单位来改进。然而，目前对于不同大麻产品或给药方法之间如何计量或标准化单位尚未达成共识。关于标准大麻单位的现有建议是基于具体的给药方法（例如关节），这些可能不包括其他方法，包括管道，烟枪，钝头，轻拍，汽化器，电子烟笔，食用品和液体。其他建议（如大麻克数）无法解释不同大麻产品中四氢大麻酚浓度的异质性。与酒精单位类似，我们认为标准大麻单位应反映主要活性药理成分（THC剂量）的数量。根据实验和生态数据、公众健康考虑因素和现行政策，我们建议所有大麻产品和服用方法的“标准四氢大麻酚单位”应定为5毫克四氢大麻酚。如果未来有足够的证据支持，标准CBD单位的消费可能会提供减少危害的额外策略。结论标准增量（9）-四氢大麻酚（THC）单位可能适用于所有大麻产品和给药方法，以指导消费者并促进更安全的使用模式。
Background and Aims Cannabis products are becoming increasingly diverse, and vary considerably in concentrations of increment (9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). Higher doses of THC can increase the risk of harm from cannabis, while CBD may partially offset some of these effects. Lower Risk Cannabis Use Guidelines currently lack recommendations based on quantity of use, and could be improved by implementing standard units. However, there is currently no consensus on how units should be measured or standardized among different cannabis products or methods of administration. Argument Existing proposals for standard cannabis units have been based on specific methods of administration (e.g. joints) and these may not capture other methods, including pipes, bongs, blunts, dabbing, vaporizers, vape pens, edibles and liquids. Other proposals (e.g. grams of cannabis) cannot account for heterogeneity in THC concentrations among different cannabis products. Similar to alcohol units, we argue that standard cannabis units should reflect the quantity of primary active pharmacological constituents (dose of THC). On the basis of experimental and ecological data, public health considerations and existing policy, we propose that a 'standard THC unit' should be fixed at 5 mg THC for all cannabis products and methods of administration. If supported by sufficient evidence in future, consumption of standard CBD units might offer an additional strategy for harm reduction. Conclusions Standard increment (9)-tetrahydrocannabinol (THC) units can potentially be applied among all cannabis products and methods of administration to guide consumers and promote safer patterns of use.