Multiwave associations between depressive symptoms and endothelial function in adolescent and young adult females.
Multiwave associations between depressive symptoms and endothelial function in adolescent and young adult females.
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DOI：
10.1097/psy.0b013e3182228644
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发表时间：
2011-07
影响因子：
3.3
通讯作者：
Puterman E
中科院分区：
文献类型：
--
作者：
Tomfohr LM;Murphy ML;Miller GE;Puterman E
抑郁症与内皮功能障碍有关，一些研究表明，过去的抑郁症发作与内皮细胞的持久负面影响有关。然而，这一领域的调查主要是横向的，引发了人们对这些协会的方向的疑问。使用多波设计，我们试图通过检查抑郁症状是否对内皮功能产生持久的负面影响来扩展该领域的先前研究。对总共 135 名没有已知或疑似重大健康问题的青少年和年轻女性进行了为期 2.5 年的跟踪调查。在整个研究的三个时间点评估内皮功能。管理贝克抑郁量表，并每 6 个月收集一次有关健康实践的信息。自我报告的抑郁症状与人体内内皮功能相关（β = -0.23，p < .05）。当参与者的抑郁症状超出其典型水平时，她的内皮功能也会相应下降。在控制了健康习惯和肥胖之后，这种关联仍然存在。没有证据表明抑郁症状可以预测稍后时间点的内皮功能或与时间相互作用来预测随访期间内皮功能的轨迹。在这组健康的青春期女孩和年轻女性中，抑郁症状与内皮功能同时相关。在访问中，当参与者认可的抑郁症状高于其平均抑郁水平时，他们的内皮功能往往较差。我们没有观察到抑郁症对内皮功能的持久负面影响。
Depression has been linked to endothelial dysfunction, and some research suggests that past depressive episodes are associated with a lasting, negative impact on the endothelium. However, investigations in this area have been predominantly cross-sectional, raising questions about the direction of these associations. Using a multiwave design, we sought to extend previous research in this area by examining whether depressive symptoms have a lasting negative influence on endothelial function. A total of 135 adolescent and young adult females with no known or suspected major health problems were followed for 2½ years. Endothelial function was assessed at three time points throughout the study. The Beck Depression Inventory was administered, and information about health practices was collected every 6 months. Self-reported depressive symptoms covaried with endothelial functioning on a within-person basis (β = −0.23, p < .05). As a participant’s depression symptoms rose beyond her typical level, her endothelial function declined commensurately. This association persisted after controlling for health practices and adiposity. There was no evidence that depressive symptoms predicted endothelial function at later time points or interacted with time to predict the trajectories of endothelial function over the follow-up period. Depressive symptoms were concurrently associated with endothelial function in this cohort of healthy adolescent girls and young women. On visits when participants endorsed depressive symptoms that were higher than their mean level of depression, they tended to have worse endothelial function. We did not observe a lasting negative effect of depression on endothelial function.