Accurate source imaging based on high resolution scalp electroencephalography and individualized finite difference head models in epilepsy pre-surgical workup
Accurate source imaging based on high resolution scalp electroencephalography and individualized finite difference head models in epilepsy pre-surgical workup
复制标题
基于高分辨率头皮脑电图和个性化有限差分头部模型的精确源成像在癫痫术前检查中的应用
DOI：
10.1016/j.seizure.2018.05.009
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发表时间：
2018-07-01
影响因子：
3
通讯作者：
Pan, Li
中科院分区：
文献类型：
--
作者：
Feng, Rui;Hu, Jie;Pan, Li
目的：高密度脑电图源成像（HD-ESI）已成为癫痫术前检查的有用工具。然而，由于几个因素，其未常规用于临床评价，其中之一是与创建解剖学上准确的头部模型相关的挑战。合理的解决方案，现在存在，本研究的目的是评估使用这些高分辨率的个人头部模型在术前癫痫evaluation.Methods：9例顽固性癫痫切除癫痫手术的候选人参加了这项研究。对于每例患者，沿着采集256通道脑电图数据以及用于构建个体有限差分模型（iFDM）的个体结构MRI数据。使用多个标准评价基于iFDM的HD-ESI（HD-ESI-iFDM）的准确性，包括与颅内脑电图（icEEG）的一致性和手术切除部位。HD-ESI-iFDM的性能也进行了比较，对MRI和正电子发射断层扫描（PET）results.Results：在所有的患者，但一个切除手术导致无并发症的结果。来源于HD-ESI-iFDM的源位置与手术切除和icEEG数据（如可用）一致。HD-ESI-iFDM还有助于规划颅内电极植入。与MRI或PET相比，HD-ESI-iFDM提供了更准确的致痫区定位。结论：当采集高密度传感器阵列和源成像与解剖学上准确的头部模型进行，脑电图可以有助于有意义的癫痫术前检查的致痫区定位。既然高密度脑电图和个体化FDM模型都可以常规获得，它可以作为临床实践的一部分。(C)2018年英国癫痫协会由爱思唯尔有限公司出版。保留所有权利。
Purpose: High-density electroencephalographic source imaging (HD-ESI) has emerged as a useful tool for pre-surgical epilepsy workup. However, it is not routinely used in clinical evaluations due to several factors, one of which is the challenge associated with creating anatomically accurate head models. Reasonable solutions now exist and the present study aims to evaluate the use of these highly resolved individual head models in pre-surgical epilepsy evaluation.Methods: Nine patients with intractable epilepsy who were candidates for resective epilepsy surgeries participated in the study. For each patient, 256-channel electroencephalography data were acquired along with individual structural MRI data that was used to construct individual finite difference models (iFDM). Accuracy of HD-ESI based on iFDM (HD-ESI-iFDM) was evaluated using multiple criteria, including concordance with intracranial electroencephalography (icEEG) and location of surgical resection. Performance of HD-ESI-iFDM was also compared against MRI and positron emission tomography (PET) results.Results: In all but one patient resective surgeries resulted in seizure-free outcome. Source locations derived from HD-ESI-iFDM demonstrated concordance with surgical resection and with icEEG data, when available. The HD-ESI-iFDM also contributed to the planning of intracranial electrodes implantation. Compared to MRI or PET, HD-ESI-iFDM provided more accurate localization of the epileptogenic zone.Conclusion: When acquired with high-density sensor arrays and source imaging is performed with anatomically accurate head models, electroencephalography can contribute meaningfully to epilepsy pre-surgical workup for localization of the epileptogenic zone. Now that both high-density electroencephalography and individualized FDM models can be routinely obtained, it can be incorporated as part of clinical practice. (C) 2018 British Epilepsy Association. Published by Elsevier Ltd. All rights reserved.