Cell-Based Therapy for the Deficient Urinary Sphincter
Cell-Based Therapy for the Deficient Urinary Sphincter
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DOI：
10.1007/s11934-013-0352-7
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发表时间：
2013-10-01
影响因子：
2.6
通讯作者：
Aicher, Wilhelm K.
中科院分区：
文献类型：
--
作者：
Hart, Melanie L.;Neumayer, Katharina M. H.;Aicher, Wilhelm K.
当哺乳动物细胞的无菌培养技术首次成为最先进的技术时，人们对这种细胞最终可用于治疗目的抱有极大的期望。成年人干细胞或祖细胞的发现进一步激励科学家们进行基于细胞的疗法的研究。虽然动物研究的证据表明，细胞的应用产生了可测量的好处，在泌尿学和许多其他学科，基于祖细胞的疗法还没有常规的临床可用。压力性尿失禁（SUI）是一种影响大量患者的疾病。SUI的病因包括但不限于尿道括约肌组织的变性和神经支配的丧失，以及解剖学和生物力学原因。因此，开发了不同的方案来治疗SUI。然而，目前，治愈性功能性治疗并不在手边。基于祖细胞的治疗可以解决尿失禁的病因，而不是后果，是一个有前途的策略。因此，几个研究小组已经加紧努力开发这种治疗失禁的方法。在这里，我们介绍了候选干细胞和祖细胞适合SUI治疗，显示如何功能的同质性和状态的分化细胞的成熟，适当的组织整合至关重要，可以评估电生理之前，他们的临床应用，并讨论营养潜力的成人间充质基质（或干）细胞在神经元功能的再生。
When sterile culture techniques of mammalian cells first became state of the art, there was tremendous anticipation that such cells could be eventually applied for therapeutic purposes. The discovery of adult human stem or progenitor cells further motivated scientists to pursue research in cell-based therapies. Although evidence from animal studies suggests that application of cells yields measurable benefits, in urology and many other disciplines, progenitor-cellbased therapies are not yet routinely clinically available. Stress urinary incontinence (SUI) is a condition affecting a large number of patients. The etiology of SUI includes, but is not limited to, degeneration of the urinary sphincter muscle tissue and loss of innervation, as well as anatomical and biomechanical causes. Therefore, different regimens were developed to treat SUI. However, at present, a curative functional treatment is not at hand. A progenitor-cell-based therapy that can tackle the etiology of incontinence, rather than the consequences, is a promising strategy. Therefore, several research teams have intensified their efforts to develop such a therapy for incontinence. Here, we introduce candidate stem and progenitor cells suitable for SUI treatment, show how the functional homogeneity and state of maturity of differentiated cells crucial for proper tissue integration can be assessed electrophysiologically prior to their clinical application, and discuss the trophic potential of adult mesenchymal stromal (or stem) cells in regeneration of neuronal function.