Brain β-amyloid load approaches a plateau
Brain β-amyloid load approaches a plateau
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DOI：
10.1212/wnl.0b013e3182840bbe
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发表时间：
2013-03-01
期刊：
影响因子：
9.9
通讯作者：
Petersen, Ronald C.
中科院分区：
文献类型：
--
作者：
Jack, Clifford R., Jr.;Wiste, Heather J.;Petersen, Ronald C.
目的：模拟时间轨迹的β-淀粉样蛋白的积累，使用串行淀粉样蛋白PET imaging.Methods：参与者，年龄在70-92岁，被招募到无论是马约诊所研究老化（n = 246）或马约阿尔茨海默氏病研究中心（n = 14）。所有患者均接受了2次或2次以上的淀粉样蛋白PET检查。有205名参与者被归类为认知正常，55名认知受损（47名轻度认知障碍和8名阿尔茨海默氏痴呆）。我们测量了基线淀粉样蛋白PET相对标准化摄取值（SUVR），并为每位参与者估计了代表其年度淀粉样蛋白累积率的斜率。然后，我们拟合回归模型，以预测基线淀粉样蛋白SUVR的淀粉样蛋白积累率，并评估年龄，性别，临床组和APOE作为协变量。最后，我们将淀粉样蛋白累积率与基线淀粉样蛋白PET SUVR的相关性整合为淀粉样蛋白PET SUVR与时间的相关性。在基线SUVR约2.0时，发生率增加至最大值，高于此值时发生率下降-在基线SUVR高于2.7时达到零。淀粉样蛋白积聚速率与基线SUVR呈倒U形。积分产生淀粉样蛋白PET SUVR与时间相关的S形曲线。从SUVR 1.5-2.5的平均估计时间旅行所需的时间约为15 years.Conclusion：这大约15年的时间间隔，其中淀粉样蛋白SUVR与时间曲线的斜率最大，大致呈线性，代表了一个大的二级预防干预治疗窗口。神经病学（R）2013;80：890-896
Objective: To model the temporal trajectory of beta-amyloid accumulation using serial amyloid PET imaging.Methods: Participants, aged 70-92 years, were enrolled in either the Mayo Clinic Study of Aging (n = 246) or the Mayo Alzheimer's Disease Research Center (n = 14). All underwent 2 or more serial amyloid PET examinations. There were 205 participants classified as cognitively normal and 55 as cognitively impaired (47 mild cognitive impairment and 8 Alzheimer dementia). We measured baseline amyloid PET-relative standardized uptake values (SUVR) and, for each participant, estimated a slope representing their annual amyloid accumulation rate. We then fit regression models to predict the rate of amyloid accumulation given baseline amyloid SUVR, and evaluated age, sex, clinical group, and APOE as covariates. Finally, we integrated the amyloid accumulation rate vs baseline amyloid PET SUVR association to an amyloid PET SUVR vs time association.Results: Rates of amyloid accumulation were low at low baseline SUVR. Rates increased to a maximum at baseline SUVR around 2.0, above which rates declined-reaching zero at baseline SUVR above 2.7. The rate of amyloid accumulation as a function of baseline SUVR had an inverted U shape. Integration produced a sigmoid curve relating amyloid PET SUVR to time. The average estimated time required to travel from an SUVR of 1.5-2.5 is approximately 15 years.Conclusion: This roughly 15-year interval where the slope of the amyloid SUVR vs time curve is greatest and roughly linear represents a large therapeutic window for secondary preventive interventions. Neurology (R) 2013;80:890-896