Protein-protein docking benchmark 2.0: An update
Protein-protein docking benchmark 2.0: An update
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DOI：
10.1002/prot.20560
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发表时间：
2005-08-01
影响因子：
2.9
通讯作者：
Weng, ZP
中科院分区：
文献类型：
--
作者：
Mintseris, J;Wiehe, K;Weng, ZP
我们提出了一个新版本的蛋白质-蛋白质对接基准，从下向上重建，包括更多的复合物，特别是专注于更多的unbound-unbounded测试用例。SCOP（蛋白质结构分类）用于评估该版本中复合物之间的冗余度。新的基准包括72个未结合-未结合的情况，其中52个刚体情况，13个中等难度情况，7个高难度情况，具有实质性的构象变化。此外，我们保留了12个抗体-抗原测试用例，其中抗体结构为结合形式。新的基准为评估对接方法在各种目标上的进展提供了一个平台。新版本的基准可在http://zlab.bu.edu/benchmark2上向公众提供。(c)2005 Wiley-Liss，Inc.
We present a new version of the Protein-Protein Docking Benchmark, reconstructed from the bottom up to include more complexes, particularly focusing on more unbound-unbound test cases. SCOP (Structural Classification of Proteins) Was used to assess redundancy between the complexes in this version. The new benchmark consists of 72 unbound-unbound cases, with 52 rigid-body cases, 13 medium-difficulty cases, and 7 high-difficulty cases with substantial conformational change. In addition, we retained 12 antibody-antigen test cases with the antibody structure in the bound form. The new benchmark provides a platform for evaluating the progress of docking methods on a wide variety of targets. The new version of the benchmark is available to the public at http://zlab.bu.edu/benchmark2. (c) 2005 Wiley-Liss,Inc.