IgM rheumatoid factors in mice injected with bacterial lipopolysaccharides.
IgM rheumatoid factors in mice injected with bacterial lipopolysaccharides.
复制标题
注射细菌脂多糖的小鼠体内的 IgM 类风湿因子。
DOI：
10.4049/jimmunol.122.5.2096
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发表时间：
1979
影响因子：
4.4
通讯作者：
F. Dixon
中科院分区：
文献类型：
--
作者：
S. Izui;R. Eisenberg;F. Dixon
细菌脂多糖（LPS）诱导包括无胸腺C57 BL/6裸小鼠在内的几种小鼠产生IgM类风湿因子（RF），但不诱导LPS抵抗的C3 H/HeJ小鼠产生RF。由LPS诱导的RF不仅与鼠IgG反应，而且与来自牛、山羊、豚鼠和人的IgG反应。该RF对注射LPS的反应的动力学类似于针对DNA和半抗原二硝基苯基（DNP）的抗体反应的动力学，以及总IgM产生的动力学。此外，个别血清样本的RF活性与抗DNA和抗DNP抗体和IgM的水平显着相关。因此，可以得出结论，RF的诱导是由LPS刺激的B细胞合成多克隆抗体的结果。这一观察结果表明，LPS或LPS样物质可能有助于类风湿性关节炎或某些感染性疾病患者产生RF。
Bacterial lipopolysaccharides (LPS) induced the formation of IgM rheumatoid factors (RF) in several strains of mice including athymic C57BL/6 nude mice, but not in the LPS-resistant C3H/HeJ mice. The RF induced by LPS reacted not only with murine IgG but also with IgG from cows, goats, guinea pigs, and humans. The kinetics of this RF response to injection of LPS were similar to those of antibody response against DNA and a hapten, dinitrophenyl (DNP), and to those of total IgM production. In addition, the RF activity of individual serum samples correlated significantly with levels of anti-DNA and anti-DNP antibodies and of IgM. Therefore, it is concluded that the induction of RF results from polyclonal antibody synthesis by B cells stimulated with LPS. This observation suggests that LPS or LPS-like substances may help to generate RF in patients with rheumatoid arthritis or with some infectious diseases.