Once daily controlled versus immediate release oxybutynin chloride for urge urinary incontinence
Once daily controlled versus immediate release oxybutynin chloride for urge urinary incontinence
复制标题
DOI：
10.1016/s0022-5347(05)68810-6
复制
发表时间：
1999-06-01
影响因子：
6.6
通讯作者：
Brown, JS
中科院分区：
文献类型：
--
作者：
Anderson, RU;Mobley, D;Brown, JS
目的：我们比较了每日一次控释和速释奥昔布宁治疗incontinence.Materials和Methods的有效性和安全性：这项多中心、随机、双盲、活性对照、平行研究旨在使用7天日记评估急迫性尿失禁发作。共有97名女性和8名男性（34 - 76岁）患有急迫性尿失禁或具有临床显著急迫性成分的混合性尿失禁患者入组本研究。控制后每周急迫性尿失禁发作次数从27.4次降至4.8次，奥昔布宁速释后从23.4次降至3.1次（p = 0.56），总尿失禁发作次数分别从29.3次降至6次和从26.3次降至3.8次（p = 0.6）。从基线到研究结束的每周急迫性尿失禁发作在对照组和速释奥昔布宁组也分别下降至84%和88%（p = 0.7）。41%的控释组和40%的速释组实现了尿失禁（p = 0.9）。控释组和速释组分别有68%和87%的患者报告了任何严重程度的口干（p = 0.04），中度或重度口干分别为25%和46%，（p = 0.03）。每天服用一次控释奥昔布宁的受试者与服用奥昔布宁的受试者相比，急迫性尿失禁和完全尿失禁发作的减少程度相似。奥昔布宁每日1 - 4次。据报道，控释奥昔布宁的口干发生率较低。
Purpose: We compared the efficacy and safety of once daily controlled and immediate release oxybutynin for incontinence.Materials and Methods: This multicenter, randomized, double-blind, active control, parallel study was designed to evaluate urge urinary incontinence episodes using a 7-day diary.Results: A total of 97 women and 8 men 34 to 76 years old with urge incontinence or mixed incontinence with a clinically significant urge component were enrolled in the study. The number of weekly urge incontinence episodes decreased from 27.4 to 4.8 after controlled and from 23.4 to 3.1 after immediate release oxybutynin (p = 0.56), and total incontinence episodes decreased from 29.3 to 6 and from 26.3 to 3.8, respectively (p = 0.6). Weekly urge incontinence episodes from baseline to end of study also decreased to 84% after controlled and 88% after immediate release oxybutynin (p = 0.7). Continence was achieved in 41% of the controlled and 40% of the immediate release group (p = 0.9). Dry mouth of any severity was reported by 68 and 87% of the controlled and immediate release groups, respectively (p = 0.04), and moderate or severe dry mouth occurred in 25 and 46%, respectively (p = 0.03).Conclusions: Participants taking a single daily does of controlled release oxybutynin had similar reductions in urge incontinence and total incontinence episodes compared to those taking oxybutynin 1 to 4 times daily. A lower incidence of dry mouth was reported for controlled release oxybutynin.