Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents
Infant nutrition and maternal obesity influence the risk of non-alcoholic fatty liver disease in adolescents
复制标题
DOI：
10.1016/j.jhep.2017.03.029
复制
发表时间：
2017-09-01
影响因子：
25.7
通讯作者：
Olynyk, John K.
中科院分区：
文献类型：
--
作者：
Ayonrinde, Oyekoya T.;Oddy, Wendy H.;Olynyk, John K.
背景和目标：青少年非酒精性脂肪性肝病（NAFLD）的途径可能起源于儿童时期建立的肥胖增加，营养和久坐的生活方式。关于婴儿营养与随后的NAFLD之间的关联，目前还缺乏足够的知识。我们研究了产妇因素和婴儿营养的关联，随后诊断NAFLD在adolescents.Methods：青少年年龄在17岁的西澳大利亚州妊娠（雷恩）队列研究脂肪肝评估使用肝脏超声。在青春期后期，对母亲怀孕和婴儿喂养的数据进行了检查，以防止NAFLD的结果。结果：在1,170名接受检查的青少年中，15.2%的人被诊断为NAFLD。94%的人在婴儿时期接受母乳喂养。在开始补充牛奶之前，54.4%的母乳喂养持续时间≥ 4个月，40.6%的母乳喂养持续时间≥ 6个月。母乳喂养，不补充牛奶>= 6个月（校正比值比[OR]：0.64; 95%置信区间[CI]：0.43-0.94，p = 0.02），母亲孕前肥胖（校正OR：2.29; 95% CI：1.21-4.32，p = 0.01）和青少年肥胖（调整OR：9.08; 95%CI：6.26-13.17，p < 0.001）与17岁时的NAFLD相关，与西方饮食模式无关。与母乳喂养≥ 6个月的青少年相比，母乳喂养≥ 6个月的NAFLD青少年的不良代谢特征较少。
Background & Aims: The pathway to non-alcoholic fatty liver disease (NAFLD) in adolescents may have its origins in adiposity gains, nutrition and sedentary lifestyle established during childhood. There is inadequate knowledge regarding the associations between infant nutrition and subsequent NAFLD. We examined the association of maternal factors and infant nutrition, with the subsequent diagnosis of NAFLD in adolescents.Methods: Adolescents aged 17 years in the Western Australian Pregnancy (Raine) Cohort study had fatty liver assessment using liver ultrasound. Prospectively recorded data on maternal pregnancy and infant feeding were examined against a NAFLD outcome during late adolescence.Results: NAFLD was diagnosed in 15.2% of the 1,170 adolescents examined. Ninety-four percent had been breastfed as infants. The duration of breastfeeding before starting supplementary milk was >= 4 months in 54.4% and >= 6 months in 40.6%. Breastfeeding without supplementary milk >= 6 months (adjusted odds ratio [OR]: 0.64; 95% confidence interval [CI]: 0.43-0.94, p = 0.02), maternal pre-pregnancy obesity (adjusted OR: 2.29; 95% CI: 1.21-4.32, p = 0.01) and adolescent obesity (adjusted OR: 9.08; 95% CI: 6.26-13.17, p < 0.001) were associated with NAFLD independent of a Western dietary pattern at 17 years of age. Adolescents with NAFLD who had been breastfed for >= 6 months had a less adverse metabolic profile compared with adolescents breastfed for