Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
Effects of aluminum on the nervous system and its possible link with neurodegenerative diseases.
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DOI：
10.3233/jad-2005-8210
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发表时间：
2005
期刊：
影响因子：
--
通讯作者：
M. Kawahara
中科院分区：
文献类型：
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作者：
M. Kawahara
铝在环境中含量丰富，但不是必需元素。铝与几种神经退行性疾病有关，如透析性脑病、肌萎缩侧索硬化症和基伊半岛和关岛的帕金森氏痴呆症，特别是阿尔茨海默病。虽然这种关联仍然存在争议，但越来越多的证据表明金属稳态在阿尔茨海默病发病机制中的作用。铝、锌、铜和铁引起阿尔茨海默氏症淀粉样β蛋白的构象变化。Al导致实验动物中tau蛋白和淀粉样β蛋白的积累。铝诱导神经元凋亡在体内以及在体外。此外，铝和铁稳态或钙稳态之间的关系已被提出。基于这些发现，铝神经毒性的特点进行了综述，并重新考虑铝与神经退行性疾病之间的潜在联系。
Aluminum is environmentally abundant, but not an essential element. Aluminum has been associated with several neurodegenerative diseases, such as dialysis encephalopathy, amyotrophic lateral sclerosis and Parkinsonism dementia in the Kii peninsula and Guam, and in particular, Alzheimer's disease. Although this association remains controversial, there is increasing evidence which suggests the implication of metal homeostasis in the pathogenesis of Alzheimer's disease. Aluminum, zinc, copper, and iron cause the conformational changes of Alzheimer's amyloid-beta protein. Al causes the accumulation of tau protein and amyloid-beta protein in experimental animals. Aluminum induces neuronal apoptosis in vivo as well as in vitro. Furthermore, a relationship between aluminum and the iron-homeostasis or calcium-homeostasis has been suggested. Based on these findings, the characteristics of aluminum neurotoxicity are reviewed, and the potential link between aluminum and neurodegenerative diseases is reconsidered.