Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival
Tumour heterogeneity in non-small cell lung carcinoma assessed by CT texture analysis: a potential marker of survival
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DOI：
10.1007/s00330-011-2319-8
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发表时间：
2012-04-01
影响因子：
5.9
通讯作者：
Miles, Ken
中科院分区：
文献类型：
--
作者：
Ganeshan, Balaji;Panayiotou, Elleny;Miles, Ken
为探讨非小细胞肺癌（NSCLC）的肿瘤异质性，通过CT纹理分析（CTTA）对54例接受18-氟脱氧葡萄糖（FDG）PET-CT分期的NSCLC患者的原发性肺部病变的非增强图像进行CTTA评估。CTTA包括图像过滤，以提取精细、中等和粗糙特征，并量化过滤图像内的像素值分布（均匀性）。采用Kaplan-Meier分析确定了PET和CTTA参数与患者生存率相关的阈值，中位生存期为29.5（1-38）个月。24、10、14和6例患者分别患有肿瘤I、II、III和IV期。PET分期和CTTA评估的肿瘤异质性是生存率的显著独立预测因素（PET分期：比值比3.85，95%置信区间0.9-8.09，P = 0.002; CTTA：比值比56.4，95%置信区间4.79-666，P = 0.001）。SUV与生存率无显著相关性。通过CTTA非增强图像评估肿瘤异质性有可能提供一种新的，非小细胞肺癌患者生存率独立预测因子。a欧洲中心计算机断层扫描是非小细胞肺癌的常规分期程序。可以量化这些肺肿瘤中的异质性。Euro cent CTTA似乎为NSCLC患者的生存提供了一种新的独立预测因子。Euro cent CTTA可能有助于NSCLC患者的疾病风险分层。
To establish the potential for tumour heterogeneity in non-small cell lung cancer (NSCLC) as assessed by CT texture analysis (CTTA) to provide an independent marker of survival for patients with NSCLC.Tumour heterogeneity was assessed by CTTA of unenhanced images of primary pulmonary lesions from 54 patients undergoing F-18-fluorodeoxyglucose (FDG) PET-CT for staging of NSCLC. CTTA comprised image filtration to extract fine, medium and coarse features with quantification of the distribution of pixel values (uniformity) within the filtered images. Receiver operating characteristics identified thresholds for PET and CTTA parameters that were related to patient survival using Kaplan-Meier analysis.The median (range) survival was 29.5 (1-38) months. 24, 10, 14 and 6 patients had tumour stages I, II, III and IV respectively. PET stage and tumour heterogeneity assessed by CTTA were significant independent predictors of survival (PET stage: Odds ratio 3.85, 95% confidence limits 0.9-8.09, P = 0.002; CTTA: Odds ratio 56.4, 95% confidence limits 4.79-666, p = 0.001). SUV was not a significantly associated with survival.Assessment of tumour heterogeneity by CTTA of non-contrast enhanced images has the potential for to provide a novel, independent predictor of survival for patients with NSCLC.aEuro cent Computed tomography is a routine staging procedure in non-small cell lung canceraEuro cent CT texture analysis (CTTA) can quantify heterogeneity within these lung tumoursaEuro cent CTTA seems to offer a novel independent predictor of survival for NSCLCaEuro cent CTTA could contribute to disease risk-stratification for patients with NSCLC.