Determination of total arsenic concentrations in biological matrices by inductively coupled plasma mass spectrometry
Determination of total arsenic concentrations in biological matrices by inductively coupled plasma mass spectrometry
复制标题
DOI：
10.1039/ja9940901379
复制
发表时间：
1994
影响因子：
3.4
通讯作者：
M. Campbell;C. Demesmay;M. Ollé
中科院分区：
文献类型：
--
作者：
M. Campbell;C. Demesmay;M. Ollé
微量元素形态分析在评估特定微量元素的营养益处或毒理学威胁中的重要性正变得越来越受到广泛的重视。为了能够提供有意义的结果，分析员必须首先能够准确测定给定基质中元素的总浓度，并且物质浓度之和必须等于总浓度，在实验误差范围内。在参加欧洲联盟测量和测试小组组织的一些初步砷形态研究时，观察到总砷含量超过了其认证值或指示值。该误差的来源已被确定为主要由样品和外部校准品之间的酸度差异引起。在这项研究的过程中，观察到的元素特定的增强（高达5倍）和一个假设来解释这一观察建议。使用基质匹配技术，最大限度地减少酸度和碳负载的差异，获得了准确的结果。
The importance of trace element speciation in the assessment of the nutritive benefit or toxicological threat of a given trace element is becoming more widely appreciated. In order to be able to furnish meaningful results, the analyst must first be able to determine accurately the total concentration of the element in a given matrix and the sum of the species concentrations must be equal to the total concentration, within experimental error. Whilst participating in some preliminary As speciation studies organized by the European Unions' Measurement and Testing group it was observed that total As levels were in excess of their certified or indicative values. The source of this error has been identified as arising principally from differences in acidity between the samples and external calibrants. In the course of this study, an element-specific enhancement of As was observed (up to a factor of 5) and a hypothesis to explain this observation is suggested. Accurate results were obtained using a matrix matching technique which minimized differences in acidity and carbon loading.