Allergic contact dermatitis due to diclofenac sodium in eye drops
Allergic contact dermatitis due to diclofenac sodium in eye drops
复制标题
滴眼液中双氯芬酸钠引起的过敏性接触性皮炎
DOI：
10.1111/j.1346-8138.2010.00934.x
复制
发表时间：
2011
期刊：
影响因子：
3.1
通讯作者：
Uezato H.
中科院分区：
文献类型：
--
作者：
Miyazato H;Yamaguchi S;Taira K;Asato Y;Yamamoto Y;Hagiwara K;Uezato H.
眼睑皮炎和/或眼周皮炎（艾德/PD）常见于多种皮肤病如脂溢性皮炎、特应性皮炎和银屑病中，但最常与变应性接触性皮炎（ACD）相关。本文描述了一例82岁男性的ACD病例;他使用0.1%双氯芬酸钠滴眼液，眼睑出现红斑。双氯芬酸钠滴眼液斑贴试验阳性。进一步的斑贴试验显示对双氯芬酸钠（双氯芬酸钠，2-[2，6-二氯苯胺]苯乙酸盐）呈阳性反应，双氯芬酸钠是滴眼液药物的主要成分。双氯芬酸钠是一种非甾体抗炎药（NSAID），常用于日常口服药物、外用软膏、凝胶剂和滴眼液。双氯芬酸钠滴眼液引起ACD的病例报告极为罕见。然而，当艾德/PD患者有双氯芬酸钠滴眼液使用史时，有必要考虑双氯芬酸钠导致的ACD。
Eyelid dermatitis and/or periocular dermatitis (ED/PD) is commonly seen in a variety of skin diseases such as seborrheic dermatitis, atopic dermatitis and psoriasis, but is most often associated with allergic contact dermatitis (ACD). Here, a case of ACD in an 82‐year‐old man is described; he used 0.1% diclofenac sodium eye drops and exhibited pruritic erythema on the eyelids. Patch test for diclofenac sodium eye drops was positive. Further patch tests revealed a positive reaction to diclofenac sodium (monosodium 2‐[2, 6‐dichlorophenylamino] phenylacetate), which was the main component in the eye drop medicine. Diclofenac sodium is a non‐steroidal anti‐inflammatory drug (NSAID), and is frequently used in everyday oral medications, topical ointments, gel agents and eye drops. Case reports on ACD caused by diclofenac sodium eye drops are extremely rare. Nevertheless, it is necessary to consider ACD due to diclofenac sodium when a patient with ED/PD has a history of use of diclofenac sodium eye drops.