Incorporation of isotopically labeled cocaine into human hair: race as a factor.
Incorporation of isotopically labeled cocaine into human hair: race as a factor.
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DOI：
10.1093/jat/22.2.156
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发表时间：
1998-03
影响因子：
2.5
通讯作者：
Gary L. Henderson;M. Harkey;Chihong Zhou;Reese T. Jones;Peyton Jacob
中科院分区：
文献类型：
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作者：
Gary L. Henderson;M. Harkey;Chihong Zhou;Reese T. Jones;Peyton Jacob
为了评估种族作为影响药物掺入人类头发的可能因素，在受控实验室条件下，对 9 名非白人男性志愿者鼻内注射 2 mg/kg 氘标记可卡因 (cocaine-d5)。连续采集三天的血液样本，并在给药后 24 小时和 72 小时采集头皮毛发样本，并每隔一个月采集一次，持续长达 12 个月。然后通过气相色谱-质谱法分析样品中的可卡因-d5 和苯甲酰麦角碱-d5 (BZE-d5)。我们将这些非白人受试者头发中发现的可卡因-d5 含量与在相同条件下接受相同剂量可卡因的白人受试者头发中发现的可卡因-d5 含量进行了比较，这是我们之前报道的一项研究的一部分。本研究中的非白人受试者头发中的可卡因-d5 含量比早期研究中的白人受试者高出约 2.7 倍。在 5 名非白人受试者中，服药后 24 小时内可在头发中检测到可卡因-d5。奇怪的是，尽管血浆中的可卡因 d5 达到了预期水平，但我们在给药后的任何时间都无法在非白人受试者的一根头发中检测到任何可卡因 d5。这些研究的结果表明，将可卡因掺入人类头发中可能存在种族偏见。然而，由于样本量相对较小，数据并不具有决定性。
In order to evaluate race as a possible factor affecting the incorporation of drugs into human hair, 2 mg/kg deuterium-labeled cocaine (cocaine-d5) was administered intranasally to nine male non-Caucasian volunteers under controlled laboratory conditions. Sequential blood samples were collected for up to three days, and scalp hair samples were collected at 24 and 72 h after dosing and at monthly intervals for up to 12 months. The samples were then analyzed by gas chromatography-mass spectrometry for cocaine-d5 and benzoylegonine-d5 (BZE-d5). The amounts of cocaine-d5 found in the hair of these non-Caucasian subjects were compared with the amounts of cocaine-d5 found in the hair of Caucasian subjects who received the same cocaine dose under identical conditions as part of a study we reported previously. The non-Caucasians in the present study had approximately 2.7 times more cocaine-d5 in their hair than the Caucasian subjects in the earlier study. In five of the non-Caucasian subjects, cocaine-d5 could be detected in hair within 24 h after dosing. Curiously, we were unable to detect any cocaine-d5 in one of the non-Caucasian subject's hair at any time after dosing even though cocaine-d5 was in plasma at the expected levels. The results from these studies suggest there may be a racial bias in the incorporation of cocaine into human hair; however, the data are not conclusive because of the relatively small sample size.