Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment
Biodegradable MnFe-hydroxide nanocapsules to enable multi-therapeutics delivery and hypoxia-modulated tumor treatment
复制标题
可生物降解的氢氧化锰纳米胶囊可实现多种治疗药物输送和缺氧调节肿瘤治疗
DOI：
10.1039/d0tb00243g
复制
发表时间：
2020-05-07
影响因子：
7
通讯作者：
Han, Gaorong
中科院分区：
文献类型：
--
作者：
Liao, Linhua;Cen, Dong;Han, Gaorong
开发能够调节肿瘤微环境并向目标肿瘤提供多种治疗药物的药物递送平台对于有效的癌症治疗至关重要。实现这些平台仍然是一个巨大的挑战。在此，基于MnFe氢氧化物（H-MnFe(OH)(x)）的可生物降解纳米胶囊已被开发为一种新型的货物运输，具有高负载能力和催化活性，通过缓解肿瘤组织的缺氧来实现协同治疗，提高疗效。作为概念验证，光敏剂（吲哚菁绿，ICG）和化疗药物（阿霉素，DOX）共同装载在纳米胶囊中，并在酸性肿瘤微环境中纳米胶囊降解时选择性释放，并通过近红外辐射促进。同时，纳米胶囊降解释放的 Mn2+/Fe3+ 离子催化肿瘤微环境中的 H2O2 转化为氧气，从而调节肿瘤缺氧并显着促进多模式治疗。显着的协同抗癌效果已在体外和体内得到证实，为未来的多功能治疗平台铺平了道路。
Developing drug delivery platforms that can modulate a tumor microenvironment and deliver multiple therapeutics to targeted tumors is critical for efficient cancer treatment. Achieving these platforms still remains a great challenge. Herein, biodegradable nanocapsules based on MnFe hydroxides (H-MnFe(OH)(x)) have been developed as a new type of cargo delivery with high loading capacity and catalytic activity, enabling synergetic therapy with promoted efficacy by relieving hypoxia in tumor tissues. As a proof of concept, a photosensitizer (indocyanine green, ICG) and a chemotherapeutic drug (doxorubicin, DOX) are co-loaded in nanocapsules and selectively released upon degradation of the nanocapsules in the acidic tumor microenvironment, and are promoted by near infrared irradiation. Meanwhile, Mn2+/Fe3+ ions released from the degradation of nanocapsules catalyze the conversion of H2O2 in a tumor microenvironment into oxygen, which modulates tumor hypoxia and dramatically boosts multimodal therapies. Remarkable synergistic anticancer outcomes have been demonstrated both in vitro and in vivo, paving the way towards future multifunctional therapeutic platforms.