THE T4 GENE ENCODES THE AIDS VIRUS RECEPTOR AND IS EXPRESSED IN THE IMMUNE-SYSTEM AND THE BRAIN
THE T4 GENE ENCODES THE AIDS VIRUS RECEPTOR AND IS EXPRESSED IN THE IMMUNE-SYSTEM AND THE BRAIN
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DOI：
10.1016/0092-8674(86)90590-8
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发表时间：
1986-11-07
期刊：
影响因子：
64.5
通讯作者：
AXEL, R
中科院分区：
文献类型：
--
作者：
MADDON, PJ;DALGLEISH, AG;AXEL, R
编码人表面蛋白T4的克隆的分离以及T4基因在新的细胞环境中的表达使我们能够检查该蛋白在艾滋病发病机理中的作用。我们的研究支持一种艾滋病病毒感染的机制，该机制最初涉及艾滋病病毒与细胞表面上T4分子的特定相互作用。可以在T4+转化的T和B淋巴细胞以及上皮细胞上证明这种关联。此外，所有检查的人类细胞表面上的T4的存在足以使这些细胞容易受到艾滋病病毒感染的影响。我们的数据表明，T4-AIDS病毒复合物然后通过受体介导的内吞作用内化。最后，我们发现T4基因在大脑以及淋巴样细胞中表达，为AIDS病毒的双中性粒子和淋巴细胞特征提供了解释。以这种方式，人逆转录病毒已经利用了对介导效应细胞靶标细胞相互作用重要的T淋巴细胞表面蛋白，以将AIDS病毒专门靶向T4+细胞种群。
The isolation of clones encoding the human surface protein T4, and the expression of the T4 gene in new cellular environments, have enabled us to examine the role of this protein in the pathogenesis of AIDS. Our studies support a mechanism of AIDS virus infection that initially involves the specific interaction of the AIDS virus with T4 molecules on the cell surface. This association can be demonstrated on T4+ transformed T and B lymphocytes as well as epithelial cells. Furthermore, the presence of T4 on the surface of all human cells examined is sufficient to render these cells susceptible to AIDS virus infection. Our data suggest that the T4-AIDS virus complex is then internalized by receptor-mediated endocytosis. Finally, we find that the T4 gene is expressed in the brain as well as in lymphoid cells, providing an explanation for the dual neutropic and lymphotropic character of the AIDS virus. In this manner, a T lymphocyte surface protein important in mediating effector cell-target cell interations has been exploited by a human retrovirus to specifically target the AIDS virus to populations of T4+ cells.