Drug delivery with nanospherical supramolecular cell penetrating peptide-taxol conjugates containing a high drug loading
Drug delivery with nanospherical supramolecular cell penetrating peptide-taxol conjugates containing a high drug loading
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使用含有高载药量的纳米球超分子细胞穿透肽-紫杉醇缀合物进行药物递送
DOI：
10.1016/j.jcis.2015.04.028
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发表时间：
2015-09-01
影响因子：
9.9
通讯作者：
Ding, Dan
中科院分区：
文献类型：
--
作者：
Tian, Ran;Wang, Huaimin;Ding, Dan
Hypothesis: Supramolecular nanostructures via small molecule self-assembly hold great promise for controlled delivery of hydrophobic anticancer drugs. Particularly, taxol has recently been discovered to possess excellent self-assembly property, which may provide new opportunities to develop a new class of functional supramolecular nanomaterials for drug delivery application.Experiments: A cell penetrating peptide (CPP)-taxol conjugate (Taxol-CPP) was designed and synthesized. The self-assembling property of Taxol-CPP was investigated and the resultant nanomaterials were well characterized. Subsequently, the cytotoxicity of the Taxol-CPP after self-assembly against HepG2 cancer cells was evaluated.Findings: It is found that the Taxol-CPP possesses a high drug loading of 26.4% in each molecule, which is able to self-assemble into supramolecular nanospheres. By taking advantages of the self-assembly ability of taxol, Taxol-CPP supramolecular nanospheres with a mean size of around 130 nm can be obtained, composed of only the functional peptide (CPP) and the drug (taxol). Furthermore, we have demonstrated that the Taxol-CPP nanospheres do not compromise the taxol's potency, which can also be utilized as the carriers for co-delivery of another anticancer drug (doxorubicin). (C) 2015 Elsevier Inc. All rights reserved.
