Clinical Characteristics of Pediatric-Onset and Adult-Onset Multiple Sclerosis in Hispanic Americans
Clinical Characteristics of Pediatric-Onset and Adult-Onset Multiple Sclerosis in Hispanic Americans
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DOI：
10.1177/0883073816638754
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发表时间：
2016-07-01
影响因子：
1.9
通讯作者：
Amezcua, Lilyana
中科院分区：
文献类型：
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作者：
Langille, Megan M.;Islam, Talat;Amezcua, Lilyana
多发性硬化症可以影响儿科患者。我们的目的是比较西班牙裔美国人儿童型多发性硬化症和成人型多发性硬化症的特征。这是对363例西班牙裔美国人多发性硬化病例的横断面分析，分析了人口统计学和临床特征。共有110名西班牙裔患者在18岁之前患有多发性硬化症，253名为成人多发性硬化症。两者最常见的症状是视神经炎。多灶性症状、癫痫发作和认知症状在儿童多发性硬化症中更常见（P 0.001）。成人型多发性硬化症患者的横肌萎缩更常见（P 0.001）。使用多变量分析，儿童型多发性硬化（校正比值比，0.3OR 95%置信区间0.16-0.71，P = 0.004）和美国出生（校正比值比，0.553，95%置信区间0.3-1.03，P = 0.006）不太可能有严重的行走障碍。结果表明，西班牙裔儿童多发性硬化症和成人多发性硬化症的差异，可能是重要的治疗和预后。
Multiple sclerosis can affect pediatric patients. Our aim was to compare characteristics between pediatric-onset multiple sclerosis and adult-onset multiple sclerosis in Hispanic Americans. This was a cross-sectional analysis of 363 Hispanic American multiple scleroses cases; demographic and clinical characteristics were analyzed. A total of 110 Hispanic patients presented with multiple sclerosis before age 18 and 253 as adult multiple sclerosis. The most common presenting symptoms for both was optic neuritis. Polyfocal symptoms, seizures, and cognitive symptoms at presentation were more prevalent in pediatric-onset multiple sclerosis (P .001). Transverse myelitis was more frequent in adult-onset multiple sclerosis (P .001). Using multivariable analysis, pediatric-onset multiple sclerosis (adjusted odds ratio, 0.3OR 95% confidence interval 0.16-0.71, P = .004) and being US born (adjusted odds ratio, 0.553, 95% confidence interval 0.3-1.03, P = .006) were less likely to have severe ambulatory disability. Results suggest that pediatric-onset multiple sclerosis and adult-onset multiple sclerosis in Hispanics have differences that could be important for treatment and prognosis.