Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.
Chromosomal localization of the hst oncogene and its co-amplification with the int.2 oncogene in a human melanoma.
复制标题
hst 癌基因的染色体定位及其与人类黑色素瘤中 int.2 癌基因的共扩增。
作者：
J. Adélaı̈de;M. Mattei;I. Marics;F. Raybaud;J. Planche;O. Delapeyrière;D. Birnbaum
在这份报告中，我们描述了成纤维细胞生长因子家族的两个癌基因之间的联系。利用人类中期染色体原位杂交技术，我们将hst基因定位于11号染色体q13带。这也是int.2基因的位置。此外，这两个基因在人黑素瘤中共扩增，这提高了人肿瘤中扩增可能是FGF家族基因活化机制的可能性。
In this report we described the linkage between two oncogenes of the fibroblast growth factor family. Using in situ hybridization to human metaphase chromosomes we mapped the hst gene to chromosome 11 at band q13. This is also the location of the int.2 gene. Furthermore, the two genes are co-amplified in a human melanoma, raising the possibility that amplification in human tumors may be a mechanism of activation of genes of the FGF family.