Three-dimensional High-speed Optical Coherence Tomography Imaging of Lamina Cribrosa in Glaucoma
Three-dimensional High-speed Optical Coherence Tomography Imaging of Lamina Cribrosa in Glaucoma
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DOI：
10.1016/j.ophtha.2008.09.008
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发表时间：
2009-02-01
期刊：
影响因子：
13.7
通讯作者：
Yoshimura, Nagahisa
中科院分区：
文献类型：
--
作者：
Inoue, Ryo;Hangai, Masanori;Yoshimura, Nagahisa
目的：使用光谱/傅立叶域光学相干断层扫描（SD-OCT）评估青光眼患者的视神经乳头和筛板外观，并测试SD-OCT图像上测量的筛板厚度与视野丧失之间的相关性。设计：观察性病例系列。参与者：我们评估了30例青光眼或高眼压患者的52只眼。方法：所使用的高速SD-OCT设备是为三维（3D）成像开发的原型系统。它的灵敏度为98分贝（dB），组织轴向分辨率为4.3 μ m，采集速率类似于每秒18，700次轴向扫描。对于3D分析，使用覆盖2.8 x 2.8 mm椎间盘区域的256 x 256轴向扫描的光栅扫描方案。使用3D图像处理软件在3D图像上测量筛板厚度。筛板厚度和平均偏差（MD）值之间的相关性进行了测试，使用静态自动perimetry.Main结果Measures：筛板功能，筛板厚度，和静态自动perimetry.Results值的清晰度：筛板厚度，和MD值之间的统计显着性：在3D图像上，筛板出现清晰的高反射板，是向后弯曲，并包含许多低反射率的圆形区域。正面横截面中筛板前表面下方可见的低反射率点与彩色眼底照片中代表筛板孔的点相对应。筛板的平均（1个标准差）厚度为190.5 +/- 52.7 μ m（范围，80.5-329.0）。斯皮尔曼秩和检验和线性回归分析显示筛板厚度与MD显著相关（斯皮尔曼σ = 0.744; P
Objective: To evaluate the appearance of the optic nerve head and lamina cribrosa in patients with glaucoma using spectral/Fourier-domain optical coherence tomography (SD-OCT) and to test for a correlation between lamina cribrosa thickness measured on SD-OCT images and visual field loss.Design: Observational case series.Participants: We evaluated 52 eyes of 30 patients with glaucoma or ocular hypertension.Methods: The high-speed SD-OCT equipment used was a prototype system developed for 3-dimensional (3D) imaging. It had a sensitivity of 98 decibels (dB), a tissue axial resolution of 4.3 mu m, and an acquisition rate of similar to 18,700 axial scans per second. For 3D analyses, a raster scan protocol of 256 x 256 axial scans covering a 2.8 x 2.8 mm disc area was used. Lamina cribrosa thickness was measured on 3D images using 3D image processing software. Correlation between lamina cribrosa thickness and mean deviation (MD) values obtained using static automatic perimetry were tested for statistical significance.Main Outcome Measures: Clarity of lamina cribrosa features, lamina cribrosa thickness, and MD values on static automatic perimetry.Results: On 3D images, the lamina cribrosa appeared clearly as a highly reflective plate that was bowed posteriorly and contained many circular areas of low reflectivity. The dots of low reflectivity visible just beneath the anterior surface of the lamina cribrosa in en face cross-sections corresponded with dots representing lamina pores in color fundus photographs. The mean (1 standard deviation) thickness of the lamina cribrosa was 190.5 +/- 52.7 mu m (range, 80.5-329.0). Spearman rank testing and linear regression analysis showed that lamina cribrosa thickness correlated significantly with MD (Spearman sigma = 0.744; P