Copper(I)-catalyzed aryl or vinyl addition to electron-deficient alkenes cascaded by cationic cyclization.
Copper(I)-catalyzed aryl or vinyl addition to electron-deficient alkenes cascaded by cationic cyclization.
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DOI：
10.1021/ol500033w
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发表时间：
2014-02
期刊：
影响因子：
5.2
通讯作者：
Bing Zhou;W. Hou;Ya-xi Yang;Hui-jin Feng;Yuanchao Li
中科院分区：
文献类型：
--
作者：
Bing Zhou;W. Hou;Ya-xi Yang;Hui-jin Feng;Yuanchao Li
研究了一种铜催化的外选择性芳基化和乙烯基化碳环化贫电子烯烃的方法，以提供快速有效地获得各种功能化3,3-二取代氧吲哚的途径。用该方法高效、简洁地合成了（±）-蛇黄碱和（±）-蛇黄碱。
An exoselective copper-catalyzed arylation- and vinylation-carbocyclization of electron-deficient alkenes was developed to provide rapid and efficient access to a variety of functionalized 3,3-disubstituted oxindoles. With this method, a highly efficient and concise formal synthesis of (±)-physostigmine and (±)-physovenine has been completed.