The Roles of Exosomes upon Metallic Ions Stimulation in Bone Regeneration.
The Roles of Exosomes upon Metallic Ions Stimulation in Bone Regeneration.
复制标题
DOI：
10.3390/jfb13030126
复制
发表时间：
2022-08-24
影响因子：
4.8
通讯作者：
Wang G
中科院分区：
文献类型：
--
作者：
Luo X;Xiao D;Zhang C;Wang G
Metallic ions have been widely investigated and incorporated into bone substitutes for bone regeneration owing to their superior capacity to induce angiogenesis and osteogenesis. Exosomes are key paracrine mediators that play a crucial role in cell-to-cell communication. However, the role of exosomes in metallic ion-induced bone formation and their underlying mechanisms remain unclear. Thus, this review systematically analyzes the effects of metallic ions and metallic ion-incorporated biomaterials on exosome secretion from mesenchymal stem cells (MSCs) and macrophages, as well as the effects of secreted exosomes on inflammation, angiogenesis, and osteogenesis. In addition, possible signaling pathways involved in metallic ion-mediated exosomes, followed by bone regeneration, are discussed. Despite limited investigation, metallic ions have been confirmed to regulate exosome production and function, affecting immune response, angiogenesis, and osteogenesis. Although the underlying mechanism is not yet clear, these insights enrich our understanding of the mechanisms of the metallic ion-induced microenvironment for bone regeneration, benefiting the design of metallic ion-incorporated implants.
登录
查看更多内容
影响因子：
7.5
作者：
Aquino-Martínez R;Angelo AP;Pujol FV
通讯作者：
Pujol FV
DOI：
10.1126/science.aau6977
发表时间：
2020-02-07
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Kalluri R;LeBleu VS
通讯作者：
LeBleu VS
影响因子：
4.4
作者：
Ji, Lujun;Bao, Liuliu;Feng, Xingmei
通讯作者：
Feng, Xingmei
影响因子：
4.8
作者：
Hoppe S;Albers CE;Elfiky T;Deml MC;Milavec H;Bigdon SF;Benneker LM
通讯作者：
Benneker LM
骨免疫调节对钴掺入的β-磷酸三钙的成骨作用的影响
影响因子：
14
作者：
Chen, Zetao;Yuen, Jones;Xiao, Yin
通讯作者：
Xiao, Yin