Chronic Stress Effects on Tumor: Pathway and Mechanism.
Chronic Stress Effects on Tumor: Pathway and Mechanism.
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DOI：
10.3389/fonc.2021.738252
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发表时间：
2021
影响因子：
4.7
通讯作者：
Lai D
中科院分区：
文献类型：
--
作者：
Hong H;Ji M;Lai D
慢性压力是一种情绪体验，当人们遇到他们无法适应的事情时就会发生。反复的慢性压力会增加患各种疾病的风险，如心血管疾病、抑郁症、内分泌疾病、炎症和癌症。越来越多的研究表明，在动物研究和临床研究中，慢性压力和肿瘤发生之间存在联系。慢性应激激活神经内分泌系统（下丘脑-垂体-肾上腺轴）和交感神经系统。应激激素通过多种机制促进肿瘤的发生和发展。此外，慢性应激还会影响机体的免疫功能，导致免疫监测能力下降，促进肿瘤的发生。慢性应激导致肿瘤的机制包括炎症、自噬和表观遗传学。这些因子增加肿瘤细胞的增殖和侵袭能力，改变肿瘤微环境。靶向肾上腺素能受体的拮抗剂在改善抗肿瘤活性以及化疗抗性和辐射抗性方面发挥了有益的作用。本文就这些分子机制在肿瘤发生发展中的作用进行综述，并探讨这些分子机制是否可能成为肿瘤治疗的理想靶点。
Chronic stress is an emotional experience that occurs when people encounter something they cannot adapt to. Repeated chronic stress increases the risk of a variety of diseases, such as cardiovascular disease, depression, endocrine disease, inflammation and cancer. A growing body of research has shown that there is a link between chronic stress and tumor occurrence in both animal studies and clinical studies. Chronic stress activates the neuroendocrine system (hypothalamic-pituitary-adrenal axis) and sympathetic nervous system. Stress hormones promote the occurrence and development of tumors through various mechanisms. In addition, chronic stress also affects the immune function of the body, leading to the decline of immune monitoring ability and promote the occurrence of tumors. The mechanisms of chronic stress leading to tumor include inflammation, autophagy and epigenetics. These factors increase the proliferation and invasion capacity of tumor cells and alter the tumor microenvironment. Antagonists targeting adrenergic receptors have played a beneficial role in improving antitumor activity, as well as chemotherapy resistance and radiation resistance. Here, we review how these mechanisms contribute to tumor initiation and progression, and discuss whether these molecular mechanisms might be an ideal target to treat tumor.
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