Deficits in decoding emotional facial expressions in Parkinson's disease
Deficits in decoding emotional facial expressions in Parkinson's disease
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DOI：
10.1016/s0028-3932(03)00154-4
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发表时间：
2004-01-01
期刊：
影响因子：
2.6
通讯作者：
Destée, A
中科院分区：
文献类型：
--
作者：
Dujardin, K;Blairy, S;Destée, A
基底神经节不仅与运动皮层，而且与前额叶和边缘皮质区有许多联系。因此，基底神经节损伤不仅会干扰运动功能，还会干扰认知功能和情绪处理。本研究的目的是评估帕金森病（PD）对解码情绪面部表情（EFEs）能力的影响，这是一种常用的研究非语言情绪处理的方法。方法：18例PD患者与18例年龄、学历、性别严格匹配的健康受试者参与研究。这些患者处于疾病的早期阶段，尚未接受任何抗帕金森治疗。使用标准化的定量任务评估efe的解码，其中表达强度中等，即与日常生活中经历的非常相似。一组测试还评估了执行功能。测量视觉空间知觉、抑郁和焦虑。结果：在病程早期，未经治疗的PD患者在解码efe以及执行功能方面明显受损。尽管两者与运动症状的严重程度没有显著相关性，但两者之间存在显著相关性。视觉空间知觉没有受损，患者的损害与他们的抑郁和焦虑得分无关。PD患者的efe解码障碍与系统反应偏倚有关。结论：PD病程早期，非言语情绪信息加工受到干扰。这表明，在PD中，黑质纹状体多巴胺能耗竭不仅会导致运动和认知障碍，还会导致情绪信息加工缺陷。观察到的相关模式并不能在基底节区回路完全或部分分离的功能组织的争论中采取明确的立场。(C) 2003 Elsevier Ltd.版权所有。
Introduction: The basal ganglia have numerous connections not only with the motor cortex but also with the prefrontal and limbic cortical areas. Therefore, basal ganglia lesions can disturb motor function but also cognitive function and emotion processing. The aim of the present study was to assess the consequences of Parkinson's disease (PD) on ability to decode emotional facial expressions (EFEs)-a method commonly used to investigate non-verbal emotion processing.Methods: Eighteen PD patients participated in the study, together with 18 healthy subjects strictly matched with respect to age, education and sex. The patients were early in the course of the disease and had not yet received any antiparkinsonian treatment. Decoding of EFEs was assessed using a standardized, quantitative task where the expressions were of moderate intensity, i.e. quite similar to those experienced in everyday life. A set of tests also assessed executive function. Visuospatial perception, depression and anxiety were measured.Results: Early in the course of the disease, untreated PD patients were significantly impaired in decoding EFEs, as well as in executive function. The deficits were significantly interrelated, although neither was significantly related to severity of the motor symptoms. Visuospatial perception was not impaired, and the patients' impairment was related neither to their depression nor to their anxiety score. The PD patients' impairment in decoding EFEs was related to a systematic response bias.Conclusion: Early in the course of PD, non-verbal emotional information processing is disturbed. This suggests that in PD, nigrostriatal dopaminergic depletion leads not only to motor and cognitive disturbances but also to emotional information processing deficits. The observed correlation pattern does not enable adoption of a clear-cut position in the debate over totally or partially segregated functional organization of the basal ganglia circuits. (C) 2003 Elsevier Ltd. All rights reserved.