Renal metastases from thyroid papillary carcinoma: study of sodium iodide symporter expression.
Renal metastases from thyroid papillary carcinoma: study of sodium iodide symporter expression.
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甲状腺乳头状癌肾转移：碘化钠同向转运蛋白表达的研究。
DOI：
10.1089/10507250152484664
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发表时间：
2001
期刊：
影响因子：
--
通讯作者：
Sarlis,NJ
中科院分区：
文献类型：
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作者：
Smallridge,RC;Castro,MR;Morris,JC;Young,PR;Reynolds,JC;Merino,MJ;Sarlis,NJ
甲状腺癌的肾脏转移是罕见的。我们报告了两个这样的病人，并证明肾转移瘤体内131 I摄取与高水平的钠有关。 第1例为碘离子（Na+/I-）同向转运体（NIS）表达。病例1：一名61岁女性患有甲状腺乳头状癌-滤泡变异型（PTC-FV），出现肩胛转移。甲状腺术后 肩胛骨切除术后，131 I治疗后扫描显示左上象限摄取。通过肾部分切除术去除了3.0 cm的转移性PTC-FV存款。病例2：一名53岁女性， 背痛。计算机断层扫描（CT）显示一个3.5厘米的肾脏肿块，多结节性甲状腺肿，肺转移认为继发于肾细胞癌。单侧肾切除术显示转移 PTC-FV。甲状腺切除术后，131 I治疗后扫描显示肺和骨骼转移。肿瘤组织中NIS免疫反应在原发肿瘤、肩部和肾脏中呈强阳性 病例1中的转移，以及病例2中的原发肿瘤。在病例2的肾转移中观察到斑点状的低水平NIS表达。总之，PTC-FV的肾转移可能偶尔 保持足够的NIS表达水平，使其在生活中检测。因此，在131 I成像期间腹部的强烈摄取不应被假定为生理胃肠道残留 放射性核素活度
Kidney metastases from thyroid cancer are rare. We report two such patients and demonstrate that thein vivo131I uptake by the kidney metastasis is associated with high levels of sodium iodide (Na+/I-) symporter (NIS) expression in the first case. Case 1: A 61-year-old woman with papillary thyroid carcinoma-follicular variant (PTC-FV) presented with scapular metastasis. After thyroidectomy and scapulectomy, a131I posttherapy scan showed left upper quadrant uptake. A 3.0-cm metastatic PTC-FV deposit was removed by partial nephrectomy. Case 2: A 53-year-old woman presented with back pain. A computed tomography (CT) scan showed a 3.5-cm renal mass, a multinodular goiter, and lung metastases thought secondary to a renal cell carcinoma. A unilateral nephrectomy revealed metastatic PTC-FV. After thyroidectomy, a131I post-therapy scan showed lung and skeletal metastases. NIS immunoreactivity in tumoral tissue was strongly positive in the primary tumor, shoulder, and kidney metastasis in case 1, as well as in the primary tumor in case 2. Spotty, low-level NIS expression was observed in the kidney metastasis in case 2. In conclusion, kidney metastases of PTC-FV may occasionally retain adequate levels of NIS expression, enabling their detection during life. Thus, intense uptake in the abdomen during 131I imaging should not be assumed to be physiological gastrointestinal tract residual radionuclide activity.