Inhibition of adenosine deaminase and of platelet aggregation by 2-azidoadenosine, a photolysable analogue of adenosine
Inhibition of adenosine deaminase and of platelet aggregation by 2-azidoadenosine, a photolysable analogue of adenosine
复制标题
2-叠氮腺苷（腺苷的光解类似物）抑制腺苷脱氨酶和血小板聚集
DOI：
--
复制
发表时间：
1976
期刊：
影响因子：
--
通讯作者：
G. Born
中科院分区：
文献类型：
--
作者：
N. Cusack;G. Born
腺苷的光解类似物2-叠氮腺苷能强烈抑制ADP诱导的人血小板聚集。腺苷脱氨酶（E. C. 3.5.4.4）被2-叠氮腺苷竞争性抑制。在2-叠氮腺苷存在下，酶被u.五、辐射。在蛋白质清除剂的存在下，失活减少。
Aggregation of human blood platelets induced by ADP was strongly inhibited by 2-azidoadenosine, a photolysable analogue of adenosine. The deamination of adenosine by adenosine deaminase (E. C. 3.5.4.4) was competitively inhibited by 2-azidoadenosine. In the presence of 2-azidoadenosine the enzyme was inactivated by u. v. radiation. The inactivation was diminished in the presence of a protein scavanger.