TREATMENT OF FULMINANT HEPATIC FAILURE BY POLYACRYLONITRILE-MEMBRANE HÆMODIALYSIS
TREATMENT OF FULMINANT HEPATIC FAILURE BY POLYACRYLONITRILE-MEMBRANE HÆMODIALYSIS
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聚丙烯腈膜血液透析治疗暴发性肝衰竭
DOI：
10.1016/s0140-6736(77)90001-0
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发表时间：
1977
期刊：
影响因子：
--
通讯作者：
Roger Williams
中科院分区：
文献类型：
--
作者：
D. Silk;P. Trewby;R. Chase;P. Mellon;M. A. Hanid;M. Davies;P. Langley;P. Wheeler;Roger Williams
24例暴发性肝功能衰竭恶化至IV级昏迷的患者采用聚丙烯腈膜反复血液透析治疗。9例患者完全恢复意识，8例（33%）存活出院。将这些结果与单纯保守治疗（53例存活率为15%）和最初用木炭血液灌注获得的结果（38%）进行比较。在16例治疗失败的病例中，13例（81%）在尸检时发现脑水肿。如果在疾病过程中更早开始治疗，这是否会成为一个更小的问题仍有待确定。
24 patients with fulminant hepatic failure who had deteriorated to grade-IV coma were treated by repeated periods of hæmodialysis with a polyacrylonitrile membrane. 9 patients fully recovered consciousness, and 8 (33%) survived to leave hospital. These results are to be compared with those of conservative management alone (15% survival in 53 cases) and those obtained initially with charcoal hæmoperfusion (38%). Of the 16 treatment failures, cerebral œdema was found at necropsy in 13 (81%). Whether this would have been less of a problem if treatment had been started earlier in the course of the illness remains to be determined.