OCCUPATIONAL EXPOSURE TO CHLORINATED ALIPHATIC-HYDROCARBONS AND RISK OF ASTROCYTIC BRAIN CANCER
OCCUPATIONAL EXPOSURE TO CHLORINATED ALIPHATIC-HYDROCARBONS AND RISK OF ASTROCYTIC BRAIN CANCER
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DOI：
10.1002/ajim.4700260203
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发表时间：
1994-08-01
影响因子：
3.5
通讯作者：
BLAIR, A
中科院分区：
文献类型：
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作者：
HEINEMAN, EF;COCCO, P;BLAIR, A
氯化脂肪烃(CAHs)被评估为星形细胞脑瘤的潜在危险因素。6个单独的CAH和一般类型的有机溶剂的工作暴露矩阵被应用于白人男性脑癌病例对照研究的数据。这些矩阵显示了在十年内(1920-1980年)是否可能在每个行业和职业中使用过CAHs，并提供了对“暴露的”行业和职业暴露的概率和强度的估计。计算每个受试者的累积暴露指数。观察到星形细胞脑癌与四氯化碳、二氯甲烷、四氯乙烯和三氯乙烯的可能接触，但对二氯甲烷的影响最大。暴露在氯仿或甲基氯仿中几乎没有迹象表明与脑癌有关。星形细胞脑瘤的风险随着暴露的概率和平均强度以及在被认为暴露于二氯甲烷的工作中工作的时间而增加，但与累积暴露分数无关。这些趋势不能用接触其他溶剂来解释。(C)1994年Wiley-Liss，Inc.*
Chlorinated aliphatic hydrocarbons (CAHs) were evaluated as potential risk factors for astrocytic brain tumors. Job-exposure matrices for six individual CAHs and for the general class of organic solvents were applied to data from a case-control study of brain cancer among white men. The matrices indicated whether the CAHs were likely to have been used in each industry and occupation by decade (1920-1980), and provided estimates of probability and intensity of exposure for ''exposed'' industries and occupations. Cumulative exposure indices were calculated for each subject.Associations of astrocytic brain cancer were observed with likely exposure to carbon tetrachloride, methylene chloride, tetrachloroethylene, and trichloroethylene, but were strongest for methylene chloride. Exposure to chloroform or methyl chloroform showed little indication of an association with brain cancer. Risk of astrocytic brain tumors increased with probability and average intensity of exposure, and with duration of employment in jobs considered exposed to methylene chloride, but not with a cumulative exposure score. These trends could not be explained by exposures to the other solvents. (C) 1994 Wiley-Liss, Inc.*