A case of primary uterine cervical neuroendocrine tumor with meningeal carcinomatosis confirmed by diagnostic imaging and autopsy
A case of primary uterine cervical neuroendocrine tumor with meningeal carcinomatosis confirmed by diagnostic imaging and autopsy
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DOI：
10.1007/s10147-010-0155-5
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发表时间：
2011-10-01
影响因子：
3.3
通讯作者：
Udagawa, Yasuhiro
中科院分区：
文献类型：
--
作者：
Komiyama, Shinichi;Nishio, Eiji;Udagawa, Yasuhiro
原发性子宫颈神经内分泌肿瘤是罕见的，但影响相对年轻的妇女和预后差，尽管多学科治疗。子宫颈恶性肿瘤引起脑膜癌病的发生率极低，英文文献中仅报道了2例子宫颈神经内分泌肿瘤引起脑膜癌病。此外，没有任何报告表明这一点在尸检中得到证实。我们遇到一位33岁的孕妇，在根治手术后被诊断为子宫颈非典型类癌。尽管进行了多药化疗（紫杉醇+依托泊苷+顺铂和伊立替康+卡铂），患者仍发生多器官转移。虽然没有转移到脑实质或脊髓实质，病人也发展成脑膜癌病。进行了全脑放射治疗，但无效。患者在初次手术后19个月和诊断为脑膜癌病后10天死亡。尸检证实存在脑膜癌病。
Primary uterine cervical neuroendocrine tumors are rare, but affect relatively young women and the prognosis is poor despite multidisciplinary treatment. The incidence of meningeal carcinomatosis arising from malignant tumors of the uterine cervix is extremely low, only two patients with meningeal carcinomatosis arising from a uterine cervical neuroendocrine tumor have been reported in the English literature. Moreover, there have been no reports in which this was confirmed at autopsy. We encountered a pregnant woman aged 33 years who was diagnosed as having atypical carcinoid of the uterine cervix after radical surgery. Despite multidrug chemotherapy (paclitaxel + etoposide + cisplatin and irinotecan + carboplatin), the patient developed multiple organ metastases. Although there was no metastasis to the brain parenchyma or the spinal cord parenchyma, the patient also developed meningeal carcinomatosis. Whole-brain radiation therapy was performed, but was ineffective. The patient died at 19 months after her initial operation and 10 days after diagnosis of meningeal carcinomatosis. The presence of meningeal carcinomatosis was confirmed at autopsy.