Low T3 syndrome is a strong prognostic predictor in diffuse large B cell lymphoma
Low T3 syndrome is a strong prognostic predictor in diffuse large B cell lymphoma
复制标题
低 T3 综合征是弥漫性大 B 细胞淋巴瘤的强预后预测因子
DOI：
10.1111/bjh.14528
复制
发表时间：
2017-04-01
影响因子：
6.5
通讯作者：
Xu, Wei
中科院分区：
文献类型：
--
作者：
Gao, Rui;Liang, Jin-Hua;Xu, Wei
本研究的目的是评价低三碘甲状腺原氨酸(T3)综合征对弥漫性大B细胞淋巴瘤(DLBCL)患者预后的影响。入选188名确诊时有详细甲状腺激素水平的患者。低T_3综合征定义为血清游离T_3(FT3)水平低，血清游离四碘甲状腺原氨酸(FT4)和促甲状腺激素水平正常或低。采用多因素Cox回归分析筛选与无进展生存期(PFS)和总生存期(OS)相关的预后因素。计算受试者特征曲线和曲线下面积，评估国际预后指数(IPI)和低T3综合征的预测准确性。24名患者被诊断为低T3综合征，在利妥昔单抗时代，这与较差的PFS和OS有关。对于PFS和OS，尤其是IPI 0-2、结外部位的患者，它是一个独立的预后因素
The aim of this study was to evaluate the prognostic effect of low triiodothyronine (T3) syndrome on patients with diffuse large B cell lymphoma (DLBCL). A hundred and eighty-eight patients with detailed thyroid hormone levels at diagnosis of DLBCL were enrolled. Low T3 syndrome was defined as a low serum free T3 (FT3) level with low or normal serum free tetraiodothyronine (FT4) and thyroid stimulating hormone levels. Multivariate Cox regression analysis was used to screen prognostic factors associated with progression-free survival (PFS) and overall survival (OS). Receiveroperator characteristic curves and the corresponding areas under the curve were calculated to assess the predictive accuracy of International Prognostic Index (IPI) and low T3 syndrome. Twenty-four patients were diagnosed with low T3 syndrome, which was associated with worse PFS and OS in the rituximab era. It was an independent prognostic factor for PFS and OS, especially for those with IPI 0-2, extranodal sites