Estrogen raises the sweating threshold in postmenopausal women with hot flashes
Estrogen raises the sweating threshold in postmenopausal women with hot flashes
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DOI：
10.1016/s0015-0282(01)03009-6
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发表时间：
2002-03-01
影响因子：
6.7
通讯作者：
Blacker, CM
中科院分区：
文献类型：
--
作者：
Freedman, RR;Blacker, CM
目的：确定雌激素是否通过提高核心体温出汗阈值、减少核心体温波动和/或减少交感神经激活（通过血浆 3-甲氧基-4-羟基苯基乙二醇测量）来改善潮热。设计：实验室生理研究。地点：大学医疗中心。患者：24 名报告频繁潮热的健康绝经后妇女。干预措施：参与者被随机分配，双盲方式，口服 1 mg/d 17β-雌二醇或安慰剂，持续 90 天。主要结果指标：核心体温、核心体温波动、平均皮肤温度、胸骨出汗率、实验室潮热计数（胸骨皮肤电导）、血浆 3-甲氧基-4-羟基苯基乙二醇。结果：E-2 组血浆 E 显着增加（8 +/- 2 vs. 132 +/- 22 pg/mL）和核心体温出汗阈值（37.98 +/- 0.09 与 38.14 +/- 0.09 摄氏度）以及血浆 FSH 降低（58.8 +/- 8.9 与 40.1 +/- 7.6 mIU/mL）和潮热（1.4 +/- 0.5 与 0.6 +/- 0.6）。这些变化没有发生在安慰剂组中。任何其他措施均无显着变化。结论：E，通过提高核心体温出汗阈值来改善潮热，但不影响核心体温波动或血浆3-甲氧基-4-羟基苯基乙二醇。 （Fertil Steril(R) 22002 77: 487-90。(C)2002，美国生殖医学会。）。
Objective: To determine if estrogen ameliorates hot flashes by raising the core body temperature sweating threshold, by reducing core body temperature fluctuations, and/or by reducing sympathetic activation (as measured by plasma 3-methoxy-4-hydroxyphenylglycol).Design: Laboratory physiological study.Setting: University medical center.Patient(s): Twenty-four healthy postmenopausal women reporting frequent hot flashes.Intervention(s): Participants were randomly assigned, in double-blind fashion, to receive 1 mg/d 17beta-estradiol orally or placebo for 90 days.Main Outcome Measure(s): Core body temperature, core body temperature fluctuations, mean skin temperature, sternal sweat rate, laboratory hot flash counts (sternal skin conductance), plasma 3-methoxy-4-hydroxyphenylglycol.Result(s): The E-2 group had significant increases in plasma E, (8 +/- 2 vs. 132 +/- 22 pg/mL) and core body temperature sweating threshold (37.98 +/- 0.09 vs. 38.14 +/- 0.09degreesC) and decreases in plasma FSH (58.8 +/- 8.9 vs. 40.1 +/- 7.6 mIU/mL) and hot flashes (1.4 +/- 0.5 vs. 0.6 +/- 0.6). These changes did not occur in the placebo group. There were no significant changes in any other measure.Conclusion(s): E, ameliorates hot flashes by raising the core body temperature sweating threshold, but does not affect core temperature fluctuations or plasma 3-methoxy-4-hydroxyphenylglycol. (Fertil Steril(R) 22002 77: 487-90. (C)2002 by American Society for Reproductive Medicine.).