Superior Stability of Hydroxysafflor Yellow A in Xuebijing Injection and the Associated Mechanism.
Superior Stability of Hydroxysafflor Yellow A in Xuebijing Injection and the Associated Mechanism.
复制标题
血必净注射液中羟基红花黄A的优异稳定性及其机制。
DOI：
10.3390/molecules22122129
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发表时间：
2017-12-02
期刊：
影响因子：
--
通讯作者：
Ren X
中科院分区：
文献类型：
--
作者：
Pu W;Zhang H;Wang M;Liu Y;Sun L;Ren X
Hydroxysafflor yellow A (HSYA) is the main bioactive ingredient of XBJ injection. At first, the stability of HSYA in solution and in a Xuebijing injection was investigated, then the mechanisms of the increased stability of HSYA in the XBJ injection were investigated to provide useful information on clinical safety. HSYA stability was investigated as a function of pH and temperature in aqueous solution and an XBJ injection, following the guidelines from the International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use. Products were identified by UPLC-MS/MS. HSYA reaction followed first-order kinetics under all conditions. The half-life of HSYA in XBJ was almost 40 times longer than in aqueous solution. The activation energies of HSYA reaction in aqueous solution and XBJ were calculated to be 78.53 and 92.90 kJ∙mol−1 by using Arrhenius equation. The results indicated that HSYA was more stable in XBJ than in aqueous solution. Two products were identified and the mechanism was intra-molecular nucleophilic substitution. The excellent stability of HSYA in XBJ injection partly due to the micelles formed in the injection. The study may provide clues for compatibility in TCM prescription and also provide useful information for further preparation technology research of HSYA and assessment of clinical safety of XBJ.
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DOI：
10.3390/molecules19055925
发表时间：
2014-05-08
期刊：
Molecules (Basel, Switzerland)
影响因子：
--
作者：
Salmani JM;Asghar S;Lv H;Zhou J
通讯作者：
Zhou J
DOI：
10.1039/p29920001603
发表时间：
1992-09-01
期刊：
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 2
影响因子：
--
作者：
CISAK, A;MIELCZAREK, C
通讯作者：
MIELCZAREK, C
影响因子：
5.4
作者：
Nie, Pei-He;Zhang, Lin;Zhi, Jian-Ming
通讯作者：
Zhi, Jian-Ming
影响因子：
4.6
作者：
Oliveira, Marcelo Antonio;Yoshida, Maria Irene;Valotto, Romanelia Spessemille
通讯作者：
Valotto, Romanelia Spessemille
影响因子：
2.1
作者：
Lu Yuan-qiang;Gu Lin-hui;Huang Wei-dong
通讯作者：
Huang Wei-dong