Renal circulatory effects of acetazolamide in patients with essential hypertension
Renal circulatory effects of acetazolamide in patients with essential hypertension
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DOI：
10.1016/j.amjhyper.2005.09.014
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发表时间：
2006-03-01
影响因子：
3.2
通讯作者：
Taura, K
中科院分区：
文献类型：
--
作者：
Horita, Y;Yakabe, K;Taura, K
背景资料：报告表明，乙酰唑胺（ACZ）在动物模型中诱导所有血管的血管舒张，以及在动物模型中诱导中小肾血管的血管舒张。然而，ACZ对原发性高血压患者肾循环的影响尚不清楚。在这项研究中，我们研究了碳酸酐酶抑制剂，乙酰唑胺（ACZ），对原发性高血压患者的肾循环的影响。方法：我们直接注入ACZ 1000毫克到10例原发性高血压患者的肾动脉主干谁经历了心导管。结果：ACZ对心率、肾动脉血压（BP）、肾动脉横截面积、肾多普勒血流速度、肾血流量（RBF）和肾血管阻力（RVR）无明显影响。然而，速度-时间积分增加了11.1%+/-7.2%，从17.6 +/-1.8 cm增加到20.0 +/-3.7 cm（P =.009）; RBF增加了39%+/-21%，从300 +/-43增加到422 +/-96 mL/min/m（2）（p = 0.002）; RVR从24，351 +/-2，291降至17，651 +/-2，731达因，降低了38%+/-20%。秒cm（-5）（p
Background: Reports indicate that acetazolamide (ACZ) induces the vasodilation of all vessels in animal models, as well as in small and medium kidney vessels in animal models. However, the effect of ACZ on the renal circulation of patients with essential hypertension remains unknown. In this study we examined the effects of a carbonic anhydrase inhibitor, acetazolamide (ACZ), on the renal circulation of patients with essential hypertension.Methods: We directly infused 1000 mg of ACZ into the main renal arteries of 10 patients with essential hypertension who had undergone cardiac catheterization. We then evaluated the effects of ACZ upon heart rate, renal artery blood pressure (BP), renal artery cross-sectional area, renal Doppler blood flow velocity, renal blood flow (RBF), and renal vascular resistance (RVR).Results: The infusion of ACZ was not associated with any significant changes in heart rate or in systolic or diastolic BP. However, the velocity-time integral was increased by 11.1% +/- 7.2%, from 17.6 +/- 1.8 to 20.0 +/- 3.7 cm (P=.009); RBF was increased by 39% +/- 21%, from 300 +/- 43 to 422 +/- 96 mL/min/m(2) (p =.002); and RVR was reduced by 38% +/- 20% from 24,351 +/- 2,291 to 17,651 +/- 2,731 dynes . sec . cm(-5) (p