Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease
Elevated serum concentrations of soluble selectin and immunoglobulin type adhesion molecules in patients with inflammatory bowel disease
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DOI：
10.1007/bf02934086
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发表时间：
1997-08-01
影响因子：
6.3
通讯作者：
Manns, MP
中科院分区：
文献类型：
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作者：
Goke, M;Hoffmann, JC;Manns, MP
粘附分子介导白细胞的外渗及其在发炎组织中的积累。在本研究中，测量了 93 名炎症性肠病患者（克罗恩病，n = 65；溃疡性结肠炎，n = 28）和 58 名年龄匹配的正常对照者的粘附分子选择素（sP-和 sE-选择素）和免疫球蛋白超基因家族（sICAM-1 和 sVCAM-1）的血清浓度。与对照组（251 +/- 33 ng/ml）相比，克罗恩病（399 +/- 33 ng/ml）和溃疡性结肠炎（385 +/- 42 ng/ml）患者的 sP-选择素血清浓度（平均值+/- SEM ng/ml）增加（分别为 P = 0.0067 和 P = 0.0193）。相比之下，克罗恩病患者（58±5ng/ml）和溃疡性结肠炎患者（64±12ng/ml）的E-选择素血清水平并不显着高于对照组（53±5ng/ml），克罗恩病患者（420±19ng/ml）和溃疡性结肠炎患者（375±40ng/ml）的sICAM-1血清浓度没有显着升高。 ng/ml）与对照（297 +/- 8 ng/ml）相比升高（分别为 P = 0.0001 和 P = 0.0473）。此外，与对照组（510 +/- 31 ng/ml）相比，克罗恩病（664 +/- 43 ng/ml）和溃疡性结肠炎（963 +/- 162 ng/ml）患者的 sVCAM-1 水平升高（分别为 P = 0.0222 和 P = 0.0121）。除少数例外，可溶性粘附分子的血清水平与疾病活动指数或疾病定位没有显着相关。升高的循环选择素和免疫球蛋白超基因型粘附分子可能与膜结合形式竞争其同源配体，从而限制白细胞的滚动和稳定粘附。
Adhesion molecules mediate the extravasation of leukocytes and their accumulation in inflamed tissues. In the present study, serum concentrations of the selectin (sP- and sE-selectin) and immunoglobulin supergene family (sICAM-1 and sVCAM-1) of adhesion molecules were measured in 93 patients with inflammatory bowel disease (Crohn's disease, n = 65; ulcerative colitis, n = 28) and 58 age-matched normal controls. sP-selectin serum concentrations (mean +/- SEM ng/ml) of patients with Crohn's disease (399 +/- 33 ng/ml) and ulcerative colitis (385 +/- 42 ng/ml) were increased (P = 0.0067 and P = 0.0193, respectively) compared to controls (251 +/- 33 ng/ml). In contrast, E-selectin serum levels of patients with Crohn's disease (58 +/- 5 ng/ml) and ulcerative colitis (64 +/- 12 ng/ml) were not significantly higher than those of controls (53 +/- 5 ng/ml), sICAM-1 serum concentrations of patients with Crohn's disease (420 +/- 19 ng/ml) and those with ulcerative colitis (375 +/- 40 ng/ml) were elevated (P = 0.0001 and P = 0.0473, respectively) compared to controls (297 +/- 8 ng/ml). Further, sVCAM-1 levels of patients with Crohn's disease (664 +/- 43 ng/ml) and ulcerative colitis (963 +/- 162 ng/ml) were increased (P = 0.0222 and P = 0.0121, respectively) compared to controls (510 +/- 31 ng/ml). With few exceptions, serum levels of soluble adhesion molecules were not significantly correlated to disease activity indices or disease localization. Elevated circulating selectin and immunoglobulin supergene type adhesion molecules may compete with membrane-bound forms for their cognate ligands and thereby limit the rolling and stable adhesion of leukocytes.