BIO COMPATIBILITY IN SELECTION OF MATERIALS FOR IMPLANTATION
BIO COMPATIBILITY IN SELECTION OF MATERIALS FOR IMPLANTATION
复制标题
DOI：
10.1002/jbm.820040306
复制
发表时间：
1970-01-01
期刊：
影响因子：
--
通讯作者：
HOMSY C A
中科院分区：
文献类型：
--
作者：
HOMSY C A
在本文中，重要的因素，有助于植入材料的不相容性和功能失败的检查。这些标准在植入失败的病因学的相互作用进行了讨论，在主机响应惰性植入物和调制这种反应中存在的细胞毒性后遗症。创伤性或生物化学来源的细胞损伤被认为是通过纤维组织刺激侵入性植入物的隔离。通过动物植入研究常规定量这种反应的困难导致了快速体外技术的发展，以预测植入物释放的部分的数量和细胞毒性。这些技术是基于红外分析和原代哺乳动物组织培养与假体液材料暴露在高温下。该方案允许制定拒绝临床植入候选材料的合理标准，并接受确定性临床前动物植入研究。该程序适用于对原型或生产植入物和制造假体所用材料的常规监测。
In this paper the factors which contribute importantly to incompatibility and functional failure of implant materials are examined. The interaction of these criteria in the etiology of implant failure is discussed in terms of the host response to an inert implant and the modulation of this response in the presence of cytotoxic sequellae. Cellular injury either of traumatic or biochemical origin is seen to stimulate sequestration of the offending implant by fibrous tissue. Difficulties associated with routine quantification of such response by animal implantation studies have led to development of rapidin vitrotechniques to predict the quantity and cytotoxicity of moeities released by an implant. These techniques are based on infrared analysis and primary mammalian tissue culture with a pseudo body fluid to which materials are exposed at elevated temperature. The protocols allow formulation of rational criteria for rejection of candidate materials for clinical implantation and acceptance for definitive preclinical animal implant studies. The procedures are applicable for routine monitoring of materials accepted for fabrication of prototype or production implants and of fabricated prostheses.