Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior
Serotonin-mediated inhibition of ventral hippocampus is required for sustained goal-directed behavior
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DOI：
10.1038/s41593-019-0376-5
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发表时间：
2019-04
影响因子：
25
通讯作者：
Keitaro Yoshida;M. Drew;M. Mimura;Kenji F. Tanaka
中科院分区：
文献类型：
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作者：
Keitaro Yoshida;M. Drew;M. Mimura;Kenji F. Tanaka
维持目标导向行动的能力对于许多领域的成功至关重要，但对相应的神经基质知之甚少。使用纤维光度法监测人口的神经活动，我们表明，在持续的食物或惩罚动机的行为参与与腹侧，而不是背侧海马活动的抑制。使用光遗传学刺激，我们证明了这种抑制是目标导向行为所必需的，而腹侧海马（vHP）的光遗传学抑制增强了维持目标导向行为的能力。在持续的目标导向行为过程中vHP的抑制伴随着中缝背核而不是中缝背核的活动增加，这表明通过Htr 3a的β-胡萝卜素能信号传导是成功的目标导向行为过程中vHP抑制的机制。维持目标导向的行动可能需要抑制vHP，因为该结构在行为抑制中的作用已得到充分证实。
The ability to sustain goal-directed action is essential for success in many domains, but little is known about the corresponding neural substrates. Using fiber photometry to monitor population neural activity, we demonstrate that engagement in sustained food- or punishment-motivated behavior is associated with suppression of ventral but not dorsal hippocampal activity. Using optogenetic stimulation, we demonstrate that this suppression is required for goal-directed behavior, whereas optogenetic suppression of the ventral hippocampus (vHP) enhances the ability to sustain goal-directed behavior. Suppression of vHP during sustained goal-directed behavior was accompanied by increased activity in median but not dorsal raphe, implicating serotonergic signaling through Htr3a as a mechanism of vHP suppression during successful goal-directed behavior. Sustainment of goal-directed action may require suppression of vHP because of the structure’s well-documented role in behavioral inhibition.