SUPPRESSION OF REMYELINATION IN CNS BY X-IRRADIATION
SUPPRESSION OF REMYELINATION IN CNS BY X-IRRADIATION
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DOI：
10.1007/bf00690975
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发表时间：
1978-01-01
影响因子：
12.7
通讯作者：
PATTERSON, RC
中科院分区：
文献类型：
--
作者：
BLAKEMORE, WF;PATTERSON, RC
大鼠和猫的脊髓暴露于2000，3000或4000拉德的X射线照射，然后通过注射溶血素在背柱中产生一个区域的原发性脱髓鞘。在4000拉德照射的动物中，没有发生雪旺细胞或少突胶质细胞的髓鞘再生。与2000拉德两种类型的髓鞘再生发生，但当与未照射的对照组相比，中央髓鞘再生不太广泛，而雪旺细胞髓鞘再生的轴突的百分比更大。3000拉德的结果是可变的，一些动物的反应类似于4000拉德组，而其他动物的反应与2000拉德组相同。在4000 rad动物的持续脱髓鞘轴突中发现少突胶质细胞，它们的过程与脱髓鞘轴突相关，但很少形成髓鞘。局部细胞的辐射损伤显然是抑制髓鞘再生的原因，但不能确定这是否是由于其单独对少突胶质细胞的影响。在脱髓鞘轴突中发现的少突胶质细胞的起源进行了讨论。
Rat and cat spinal cords were exposed to 2000, 3000 or 4000 rads of X-irradiation prior to producing an area of primary demyelination in the dorsal columns by injection of lysolecithin. In animals irradiated with 4000 rads, no remyelination by Schwann cells or oligodendrocytes occurred. With 2000 rads both types of remyelination occurred, but when compared to unirradiated controls, central remyelination was less extensive, while Schwann cells remyelinated a greater percentage of axons. With 3000 rad the results were variable, some animals responded similarly to those in the 4000 rad group, whereas others responded as the 2000 rad animals. Oligodendrocytes were found among the persistently demyelinated axons in the 4000 rad animals and their processes were associated with, but only rarely formed a myelin sheath round, the demyelinated axons. Irradiation damage to local cells apparently was responsible for inhibition of remyelination, but it could not be determined if this was due to its effect on the oligodendrocytes alone. The origin of the oligodendrocytes found among the demyelinated axons is discussed.