Increased sensitivity of mice to tremorogenic agents following MPP+.
Increased sensitivity of mice to tremorogenic agents following MPP+.
复制标题
MPP 后小鼠对致颤剂的敏感性增加。
DOI：
10.1007/bf00176480
复制
发表时间：
1987
影响因子：
3.4
通讯作者：
Walsh,SL
中科院分区：
文献类型：
--
作者：
Wagner,GC;Walsh,SL
The behavioral effects following intrastriatal MPP+, the neurotoxic metabolite of MPTP, were evaluated in mice. Bilateral injections of 10 ίcro;g MPP+to mice previously trained in the shuttle box paradigm produced a 66% decrease in striatal dopamine and significant deficits in all measures of conditioned avoidance responding. In addition, although these mice showed no deficits in baseline rotorod performance, challenge with the cholinergic agonist oxotremorine revealed that MPP+-treated mice exhibited an increased sensitivity to the disruptive effects of the drug at each dose and time point. Finally, MPP+-treated mice also exhibited an increase in tremor induced by 0.1 and 0.15 mg/kg oxotremorine. These observations are discussed in reference to idiopathic parkinsonism.
