Ten- to fourteen-year effect of screening on breast cancer mortality.
Ten- to fourteen-year effect of screening on breast cancer mortality.
复制标题
筛查对乳腺癌死亡率的十年至十四年影响。
DOI：
--
复制
发表时间：
1982
期刊：
影响因子：
--
通讯作者：
R. Roeser
中科院分区：
文献类型：
--
作者：
S. Shapiro;W. Venet;P. Strax;L. Venet;R. Roeser
健康保险计划 (HIP) 进行的随机试验的结果报告的时间比以前更长，该试验旨在确定通过乳房 X 光检查和触诊进行乳腺癌筛查的效果。进入研究10年后，研究组因乳腺癌死亡率比对照组低约30%。筛选带来的算术收益一直保持到第 14 年；相对收益下降。随着随访时间的延长，仅通过乳房X光检查检测到的病例（筛查期间触诊阴性）的累积生存率比其他亚组的生存率下降得更快，但乳房X光检查病例的生存率仍然相对较高。随着随访时间的延长，参与研究时年龄为 40-49 岁的女性乳腺癌死亡率开始低于对照组。对于是否接受这一发现作为 HIP 研究条件下 50 岁以下筛查有效性的证据持保留态度。持保留态度的依据是，研究组入组时年龄为45-49岁的死亡率下降完全集中在50岁以后诊断的病例中。
Results from the randomized trial conducted by the Health Insurance Plan (HIP) to determine the efficacy of breast cancer screening with mammography and palpation are reported for longer periods than previously available. By the end of 10 years after entry, the study group's mortality due to breast cancer was about 30% below the control group's. Arithmetic gains due to screening were maintained through year 14; relative gains declined. With increases in the period of follow-up, cumulative survival rates among cases detected by mammography alone (palpation negative during screening), decreased more rapidly than rates among other subgroups, but survival rates for mammography cases remained relatively high. Study women aged 40-49 years at entry began to show lower breast cancer mortality than those in the control group as duration of follow-up increased. Reservations are advanced about the acceptance of this finding as evidence of the efficacy of screening under age 50 under the conditions of the HIP study. The reservations are based on the observation that the decrease of mortality among the study group aged 45-49 at entry is concentrated entirely among cases diagnosed after they reached 50 years of age.