Diagnostic value of PET/CT for the staging and restaging of pediatric tumors
Diagnostic value of PET/CT for the staging and restaging of pediatric tumors
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DOI：
10.1007/s00259-008-0911-1
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发表时间：
2009-01-01
影响因子：
9.1
通讯作者：
Franc, Benjamin L.
中科院分区：
文献类型：
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作者：
Kleis, Margit;Daldrup-Link, Heike;Franc, Benjamin L.
本回顾性研究的目的是比较2-[F-18]氟-2-脱氧-d -葡萄糖正电子发射断层扫描(F-18- fdg PET)/CT与单独使用F-18- fdg PET和CT对儿童实体瘤分期和再分期的诊断价值。方法43例接受F-18-FDG PET/CT影像初步分期或转移随访的骨肉瘤（n=1）、鳞状细胞癌（n=1）、滑膜肉瘤（n=2）、生殖细胞瘤（n=2）、神经母细胞瘤（n=2）、硬纤维瘤（n=2）、黑素瘤（n=3）、横纹肌肉瘤（n=5）、霍奇金淋巴瘤（n=7）、非霍奇金淋巴瘤（n=9）、尤因肉瘤（n=9）患儿和青少年（女性19例，男性24例，年龄6-20岁）。原发肿瘤的存在、位置和大小分别由两名经验丰富的审查员在PET/CT、PET和CT上确定。原发肿瘤的诊断经组织病理学证实。通过组织病理学（n=62）或临床和影像学随访（n= 238）证实转移的存在或不存在。结果F-18-FDG PET/CT联合检测实体原发性肿瘤的敏感性（95%）、单独使用F-18-FDG PET（73%）和单独使用CT（93%）差异无统计学意义（p < 0.05）。17例患者共153例远处转移。PET/CT联合检测转移灶的敏感性（91%）明显高于PET单独检测转移灶的敏感性（37%;p0.05）。当排除直径小于0.5 cm的病变时，PET/CT（89%）的特异性明显高于PET (45%), p0.5 cm和直径为
Objective The objective of this retrospective study was to compare the diagnostic value of 2-[F-18]fluoro-2-deoxy-D-glucose positron emission tomography (F-18-FDG PET)/CT versus F-18-FDG PET and CT alone for staging and restaging of pediatric solid tumors.Methods Forty-three children and adolescents (19 females and 24 males; mean age, 15.2 years; age range, 6-20 years) with osteosarcoma (n=1), squamous cell carcinoma (n=1), synovial sarcoma (n=2), germ cell tumor (n=2), neuroblastoma (n=2), desmoid tumor (n=2), melanoma (n=3), rhabdomyosarcoma (n=5), Hodgkin's lymphoma (n=7), non-Hodgkinlymphoma (n=9), and Ewing's sarcoma (n=9) who had undergone F-18-FDG PET/CT imaging for primary staging or follow-up of metastases were included in this study. The presence, location, and size of primary tumors was determined separately for PET/CT, PET, and CT by two experienced reviewers. The diagnosis of the primary tumor was confirmed by histopathology. The presence or absence of metastases was confirmed by histopathology (n=62) or clinical and imaging follow-up (n= 238).Results The sensitivities for the detection of solid primary tumors using integrated F-18-FDG PET/CT (95%), F-18-FDG PET alone (73%), and CT alone (93%) were not significantly different (p>0.05). Seventeen patients showed a total of 153 distant metastases. Integrated PET/CT had a significantly higher sensitivity for the detection of these metastases (91%) than PET alone (37%; p0.05). When lesions with a diameter of less than 0.5 cm were excluded, PET/CT (89%) showed a significantly higher specificity compared to PET (45%; p0.5 cm and lymph node metastases with a diameter of