Surface-enhanced Raman spectroscopy
Surface-enhanced Raman spectroscopy
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DOI：
10.1021/ac053456d
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发表时间：
2005-09-01
影响因子：
7.4
通讯作者：
Van Duyne, RP
中科院分区：
文献类型：
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作者：
Haynes, CL;McFarland, AD;Van Duyne, RP
SER光谱（SERS）可以用于敏感和选择性的分子鉴定。近年来，SERS作为一种信号转导机制在生物和化学传感领域得到了广泛的应用。例如农药(4)、炭疽(5)、前列腺特异性抗原(6)、葡萄糖（7,8）和核废料(9)的痕量分析。SERS也被用于细菌鉴定（10）、遗传诊断（11）和免疫测定标记（12-14）。一种小型、廉价、便携的SERS仪器使该技术在诊所、野外和城市环境中进行痕量分析（15）。自SERS发现以来的28年中，该技术已经从粗糙银电极上吡啶的模型系统研究发展到最先进的表面科学和现实世界的传感器应用。SERS研究目前平均每年产生200篇论文，并且该技术也在许多其他手稿中被引用为新兴纳米技术的应用。在过去的十年中，光谱仪器、纳米制造方法、理论建模和新型检测方案的发展已经引起了人们对SERS使用的广泛兴趣，并使该技术成为一种强大的分析工具。
SER spectroscopy (SERS) can be exploited for sensitive and selective molecular identification. Recently, SERS has been used extensively as a signal transduction mechanism in biological and chemical sensing. Examples are trace analysis of pesticides (4), anthrax (5), prostate-specific antigen (6), glucose (7, 8), and nuclear waste (9). SERS has also been implemented for identification of bacteria (10), genetic diagnostics (11), and immunoassay labeling (12–14). A miniaturized, inexpensive, and portable SERS instrument makes the technique practical for trace analysis in clinics, the field, and urban settings (15). In the 28 years since the discovery of SERS, the technique has progressed from model system studies of pyridine on a roughened silver electrode to state-of-the-art surface science and realworld sensor applications. SERS research currently produces an average of 200 papers per year, and the technique is also cited in many other manuscripts as an application for emerging nanotechnology. Over the past decade, the development of spectroscopic instrumentation, nanofabrication methods, theoretical modeling, and novel detection schemes has spawned widespread interest in the use of SERS and has established the technique as a powerful analytical tool.