A broadly implementable research course in phage discovery and genomics for first-year undergraduate students.
A broadly implementable research course in phage discovery and genomics for first-year undergraduate students.
复制标题
DOI：
10.1128/mbio.01051-13
复制
发表时间：
2014-02-04
期刊：
影响因子：
6.4
通讯作者：
Hatfull GF
中科院分区：
文献类型：
--
作者：
Jordan TC;Burnett SH;Carson S;Caruso SM;Clase K;DeJong RJ;Dennehy JJ;Denver DR;Dunbar D;Elgin SC;Findley AM;Gissendanner CR;Golebiewska UP;Guild N;Hartzog GA;Grillo WH;Hollowell GP;Hughes LE;Johnson A;King RA;Lewis LO;Li W;Rosenzweig F;Rubin MR;Saha MS;Sandoz J;Shaffer CD;Taylor B;Temple L;Vazquez E;Ware VC;Barker LP;Bradley KW;Jacobs-Sera D;Pope WH;Russell DA;Cresawn SG;Lopatto D;Bailey CP;Hatfull GF
让大量的大学生参与真正的科学发现是可取的，但很难实现。我们已经开发了一个通用模型，其中来自不同学术机构的教师和助教接受培训，为一年级本科生讲授研究课程，重点是噬菌体发现和基因组学。该课程位于旨在了解病毒多样性的更广泛的科学背景下，使教师和学生与该领域的研究人员合作。霍华德休斯医学研究所（HHMI）科学教育联盟噬菌体猎人推进基因组学和进化科学（SEA-PHAGES）课程已被广泛实施，并已在73个机构的4,800多名学生。我们在这里表明，这种联盟来源的模型不仅大大推进了噬菌体基因组学领域，而且还激发了学生对科学的兴趣，积极影响学术成就，并增强了科学，技术，工程和数学（STEM）学科的持久性。通过将其他研究领域与大量早期职业本科生相结合，这种模式的广泛应用有可能在科学教育和研究培训方面产生变革。本科生在其职业生涯的早期阶段从事科学研究提供了一个机会，激发学生对科学，技术，工程和数学（STEM）学科，并促进在这些领域的持续兴趣。已经开发了许多优秀的基于课程的本科生研究经验，但将这些扩展到更广泛的影响与更多的学生是具有挑战性的。霍华德休斯医学研究所（HHMI）科学教育联盟噬菌体狩猎推进基因组学和进化科学（SEA-PHAGES）计划利用噬菌体群体的巨大规模和多样性，让学生参与新病毒的发现，基因组注释和比较基因组学，对噬菌体研究产生强烈影响，增加STEM领域的持久性，以及学生对学习成果的自我认同，动机、态度和职业抱负。
Engaging large numbers of undergraduates in authentic scientific discovery is desirable but difficult to achieve. We have developed a general model in which faculty and teaching assistants from diverse academic institutions are trained to teach a research course for first-year undergraduate students focused on bacteriophage discovery and genomics. The course is situated within a broader scientific context aimed at understanding viral diversity, such that faculty and students are collaborators with established researchers in the field. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunters Advancing Genomics and Evolutionary Science (SEA-PHAGES) course has been widely implemented and has been taken by over 4,800 students at 73 institutions. We show here that this alliance-sourced model not only substantially advances the field of phage genomics but also stimulates students’ interest in science, positively influences academic achievement, and enhances persistence in science, technology, engineering, and mathematics (STEM) disciplines. Broad application of this model by integrating other research areas with large numbers of early-career undergraduate students has the potential to be transformative in science education and research training. Engagement of undergraduate students in scientific research at early stages in their careers presents an opportunity to excite students about science, technology, engineering, and mathematics (STEM) disciplines and promote continued interests in these areas. Many excellent course-based undergraduate research experiences have been developed, but scaling these to a broader impact with larger numbers of students is challenging. The Howard Hughes Medical Institute (HHMI) Science Education Alliance Phage Hunting Advancing Genomics and Evolutionary Science (SEA-PHAGES) program takes advantage of the huge size and diversity of the bacteriophage population to engage students in discovery of new viruses, genome annotation, and comparative genomics, with strong impacts on bacteriophage research, increased persistence in STEM fields, and student self-identification with learning gains, motivation, attitude, and career aspirations.