Benign Atypical Intravascular CD30+ T-cell Proliferation: A Reactive Condition Mimicking Intravascular Lymphoma
Benign Atypical Intravascular CD30+ T-cell Proliferation: A Reactive Condition Mimicking Intravascular Lymphoma
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DOI：
10.1097/dad.0b013e3182323119
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发表时间：
2013-04-01
影响因子：
1.1
通讯作者：
Luis Rodriguez-Peralto, Jose
中科院分区：
文献类型：
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作者：
Riveiro-Falkenbach, Erica;Teresa Fernandez-Figueras, Maria;Luis Rodriguez-Peralto, Jose
CD 30是一种跨膜糖蛋白分子，通常在活化的B和T细胞中表达。虽然它被认为是CD30淋巴瘤的可靠标志物，但反应性炎症性疾病可能含有大量的CD30（+）细胞，在临床或组织学上与淋巴增生性疾病相似。血管内淋巴瘤是一种罕见的非霍奇金淋巴瘤的变种，可涉及40%的患者的皮肤。大多数病例显示B细胞表型，只有少数病例是T细胞或NK细胞来源的。此外，2例血管内大T细胞淋巴瘤的侵袭性病例被描述为具有CD30（+）表型。在此，我们报告2例皮肤病变显示非典型血管内CD30（+）T细胞增殖。两例患者均未出现全身性疾病，因此结局良好。据我们所知，这是文献中第二份关于良性血管内CD 30（+）T细胞增殖的报告，这代表了血管内淋巴瘤的有趣鉴别诊断。
CD30 is a transmembrane glycoprotein molecule usually expressed in activated B and T cells. Although it has been considered a reliable marker for CD30 lymphomas, reactive inflammatory disorders may contain a significant number of CD30(+) cells mimicking lymphoproliferative disorders clinically or histologically. Intravascular lymphoma is a rare variant of non-Hodgkin lymphoma that can involve the skin in 40% of the patients. The majority of cases show a B-cell phenotype, and only a minority of cases are of T-cell or NK-cell origin. Moreover, 2 aggressive cases of intravascular large T-cell lymphoma have been described with a CD30(+) phenotype. Herein, we report 2 patients with skin lesions showing an atypical intravascular CD30(+) T-cell proliferation. Both the patients did not present systemic disease and therefore exhibit a favorable outcome. To the best of our knowledge, this is the second report in the literature of a benign intravascular CD30(+) T-cell proliferation that represents an intriguing differential diagnosis for intravascular lymphoma.