Midbrain-derived neurotrophins support survival of immature striatal projection neurons.
Midbrain-derived neurotrophins support survival of immature striatal projection neurons.
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DOI：
10.1523/jneurosci.3687-12.2013
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发表时间：
2013-02-20
期刊：
影响因子：
--
通讯作者：
Xu B
中科院分区：
文献类型：
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作者：
Baydyuk M;Xie Y;Tessarollo L;Xu B
神经元死亡发生在胚胎发生和出生后早期发育的几个阶段;然而，在这些细胞迁移到最终目的地之前，尚不清楚未成熟神经元在其起源处的存活是如何调节的。纹状体投射神经元，称为中型多刺神经元（MSN），在直接和间接途径中产生于外侧神经节隆起（LGE）。在这里，我们报告说，脑源性神经营养因子和神经营养素-3是从中脑多巴胺能神经元顺行运输，并支持未成熟的MSN的间接和直接途径的生存，分别在发育中的小鼠纹状体和LGE。这些结果揭示了神经系统中神经营养作用的一种新模式，通过将神经营养因子与未成熟神经元在其起源处的存活联系起来，同时还表明神经支配神经元可以控制其在大脑中的靶向神经元群体的大小。
Neuronal death occurs at several stages during embryogenesis and early postnatal development; however, it is unknown how the survival of immature neurons at their origin is regulated before these cells migrate to their final destination. Striatal projection neurons, known as medium-sized spiny neurons (MSNs), in both the direct and indirect pathways are generated in the lateral ganglionic eminence (LGE). Here we report that brain-derived neurotrophic factor and neurotrophin-3 are anterogradely transported from midbrain dopaminergic neurons and support the survival of immature MSNs of the indirect and direct pathways, respectively, in the developing mouse striatum and LGE. These results reveal a novel mode of neurotrophic action in the nervous system by linking neurotrophins to the survival of immature neurons at their origin, while also suggesting that innervating neurons may control the size of their targeting neuronal population in the brain.