The neural basis of Drosophila gravity-sensing and hearing
The neural basis of Drosophila gravity-sensing and hearing
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DOI：
10.1038/nature07810
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发表时间：
2009-03-12
期刊：
影响因子：
64.8
通讯作者：
Ito, Kei
中科院分区：
文献类型：
--
作者：
Kamikouchi, Azusa;Inagaki, Hidehiko K.;Ito, Kei
果蝇用于感知嗅觉、味觉和光的神经基质与我们的神经基质在结构和功能上有显著的相似性，这为解剖感觉刺激处理提供了有吸引力的模型。在这里，我们专注于两个剩余的和不太了解的主要感觉形式：重力感受和听觉。我们表明，苍蝇已经实现了这两种感觉方式到一个单一的系统，约翰斯顿的器官，其中包含专门的集群mechanosensory神经元，每个监测特定的运动的天线。重力和声音敏感神经元的反应特性不同，只有后者表达候选mechanotransducer通道NompC。这两个神经亚群的中枢投射也不同，它们进入的神经通路让人想起我们大脑中的前庭和听觉通路。通过建立果蝇对应的这些感觉系统，我们的研究结果提供了一个系统的功能和分子解剖的不同mechanosensory刺激是如何检测和处理的基础。
The neural substrates that the fruitfly Drosophila uses to sense smell, taste and light share marked structural and functional similarities with ours, providing attractive models to dissect sensory stimulus processing. Here we focus on two of the remaining and less understood prime sensory modalities: graviception and hearing. We show that the fly has implemented both sensory modalities into a single system, Johnston's organ, which houses specialized clusters of mechanosensory neurons, each of which monitors specific movements of the antenna. Gravity- and sound-sensitive neurons differ in their response characteristics, and only the latter express the candidate mechanotransducer channel NompC. The two neural subsets also differ in their central projections, feeding into neural pathways that are reminiscent of the vestibular and auditory pathways in our brain. By establishing the Drosophila counterparts of these sensory systems, our findings provide the basis for a systematic functional and molecular dissection of how different mechanosensory stimuli are detected and processed.