High Resolution SPECT in Small Animal Research
High Resolution SPECT in Small Animal Research
复制标题
小动物研究中的高分辨率 SPECT
DOI：
10.1515/revneuro.2001.12.2.187
复制
发表时间：
2001
影响因子：
4.1
通讯作者：
H. Müller
中科院分区：
文献类型：
--
作者：
A. Wirrwar,;N. Schramm;H. Vosberg,;H. Müller
单光子发射计算机断层扫描（SPECT）是一种用于评估体内条件下生理和生化过程的技术。SPECT利用放射性标记物质生成血流、葡萄糖代谢和受体特征的断层图像。本文综述了实验动物在改良的人和专用动物SPECT扫描仪上的体内成像技术的现状。目前，配备特殊准直器的SPECT相机的空间分辨率可达1毫米，灵敏度约为1000 cps/MBq，可以在皮摩尔范围内观察受体活性浓度的变化。这种相机的时间分辨率很大程度上取决于示踪剂的药理学行为，范围从几分钟到几小时不等。在这些限制范围内，许多过程的功能表征是可能的。SPECT还提供了建立动态研究方案和重复测量同一动物的可能性。这种技术减少了牺牲动物的需要，就像在动物相机发展之前普遍实行的那样。动物SPECT提供了在体内监测动物生理和生化过程的机会，而不会干扰观察系统，并且可能成为动物研究仪器（放射自显影，体外方法）的有价值的辅助手段。
Single Photon Emission Computed Tomography (SPECT) is a technique used to assess physiological and biochemical processes under in vivo conditions. SPECT generates tomographic images from blood flow, glucose metabolism and receptor characteristics using radioactively labelled substances. This paper reviews the state of the art of in vivo imaging of laboratory animals in modified human and dedicated animal SPECT scanners. SPECT cameras with special collimators currently reach spatial resolutions up to 1 mm and sensitivities of about 1000 cps/MBq, allowing observation of receptor activity concentration changes in the pico-mole range. The time resolution of such cameras strongly depends on the pharmacological behaviour of the tracer and can range from several minutes to hours. Within these limits the functional characterization of many processes is possible. SPECT also offers the possibility to set up dynamic study protocols and repeated measurements of the same animal. This technique reduces the need for sacrificing animals, as was commonly practiced before the development of animal cameras. Animal SPECT gives the opportunity to monitor physiological and biochemical processes in animals in vivo, without interfering with the system under observation, and may become a valuable adjunct to the instrumentation (autoradiography, in vitro methods) of animal research.
用于三维脑成像的固定半球形 SPECT 成像仪。
DOI：
--
发表时间：
1993
期刊：
Journal of nuclear medicine : official publication, Society of Nuclear Medicine
影响因子：
--
作者：
Rowe,RK;Aarsvold,JN;Barrett,HH;Chen,JC;Klein,WP;Moore,BA;Pang,IW;Patton,DD;White,TA
通讯作者：
White,TA