Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES).
Inflammation, obesity, and metabolic syndrome in depression: analysis of the 2009-2010 National Health and Nutrition Examination Survey (NHANES).
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DOI：
10.4088/jcp.14m09009
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发表时间：
2014-12
期刊：
影响因子：
--
通讯作者：
Trivedi MH
中科院分区：
文献类型：
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作者：
Rethorst CD;Bernstein I;Trivedi MH
描述一个大型抑郁症患者队列中炎症、肥胖和代谢综合征（MetS）升高的发生率，并检查抑郁症患者中炎症和代谢综合征的相互关系。对2009-2010年国家健康与营养调查（NHANES）中患者健康问卷（PHQ）-9抑郁评分≥ 10的研究参与者进行分析，以：1）检查炎症（C-反应蛋白; CRP）与人口统计学和临床特征的关系，2）检查CRP组中MetS标准的患病率。5579名参与者提供了PHQ-9数据;其中，606名PHQ-9评分≥ 10，并被纳入进一步分析。在606名抑郁症患者中，585名患者有有效的CRP数据; 275名患者（47.01%）的CRP水平≥ 3.0 mg/L，170名患者（29.06%）的CRP水平≥ 5.0 mg/L。炎症升高与体重、腰围、BMI、胰岛素、2小时葡萄糖耐量和自我报告的一般健康状况显著相关（p < 0.05）。112例（41.18%）符合AHA/NHLBI代谢综合征（MetS）标准。CRP升高的患者更有可能符合MetS标准（CRP水平≥ 3.0 mg/L的比值比为2.81，CRP水平≥ 5.0 mg/L的比值比为1.94）。超过29%的抑郁症患者CRP水平升高，41%符合MetS标准。炎症升高的个体更有可能肥胖并符合MetS的标准。这些结果突出了抑郁症患者的显著炎症和代谢负担。
To describe the rates of elevated inflammation, obesity and metabolic syndrome (MetS) within a large cohort of individuals with depression and to examine the inter-relationships of inflammation and metabolic syndrome in depressed individuals. Analyses were conducted on study participants from the 2009–2010 National Health and Nutrition Survey (NHANES) with Patient Health Questionnaire (PHQ)-9 depression scores ≥ 10 to: 1) examine the relationship of inflammation (C-reactive protein; CRP) with demographic and clinical characteristics and 2) examine the prevalence of MetS criteria within CRP groups. 5579 participants provided PHQ-9 data; of those, 606 had PHQ-9 scores ≥ 10 and were included in further analysis. Of the 606 depressed participants, 585 participants had valid CRP data; 275 participants (47.01%) had CRP levels ≥ 3.0 mg/L, while 170 (29.06%) had CRP levels ≥ 5.0 mg/L. Elevated inflammation was significantly correlated with body weight, waist circumference, BMI, insulin, 2-hour glucose tolerance, and self-report general health (p’s < 0.05). 112 subjects (41.18%) met AHA/NHLBI criteria for metabolic syndrome (MetS). Those with elevated CRP were more likely to meet criteria for MetS (Odds Ratios of 2.81 for those with CRP levels ≥ 3.0 mg/L and 1.94 for those with CRP levels ≥ 5.0 mg/L). Over 29% of depressed individuals have elevated levels of CRP and 41% met criteria for MetS. Individuals with elevated inflammation are more likely to be obese and meet criteria for MetS. These results highlight the significant inflammatory and metabolic burden of individuals with depression.