EFFECT OF PINEALECTOMY AND MELATONIN ON MAMMARY-TUMOR GROWTH IN SPRAGUE-DAWLEY RATS UNDER DIFFERENT CONDITIONS OF LIGHTING
EFFECT OF PINEALECTOMY AND MELATONIN ON MAMMARY-TUMOR GROWTH IN SPRAGUE-DAWLEY RATS UNDER DIFFERENT CONDITIONS OF LIGHTING
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DOI：
10.1007/bf01670163
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发表时间：
1980-01-01
影响因子：
3.3
通讯作者：
LECALVEZ, J
中科院分区：
文献类型：
--
作者：
AUBERT, C;JANIAUD, P;LECALVEZ, J
压力会改变生物胺（儿茶酚胺和吲哚胺，例如血清素和褪黑激素）的神经激素平衡。通过服用褪黑激素、松果体切除术或改变夜间照明周期，研究了这种神经激素平衡对肿瘤诱导和肿瘤生长的可能作用。在雌性 Sprague-Dawley 大鼠通过口服 7.12 DMBA [二甲基苯并蒽]诱发乳腺肿瘤的情况下，得到了 2 个重要的观察结果：致癌物改变了垂体血清素的水平，特别是在中叶水平，而褪黑激素似乎在限制肿瘤发展方面发挥了作用。神经激素平衡与松果体-下丘脑-垂体激素调节有关，可能通过改变外周激素分泌而在雌性大鼠乳腺肿瘤的肿瘤诱导和肿瘤生长中发挥作用。在某些实验条件下，由夜间周期改变引起的应激可以改变肿瘤反应和发育。
Stress modifies the neurohormonal balance of biogenic amines (catecholamines and indoleamines such as serotonin and melatonin). The possible role of such neurohormonal balances on tumor induction and tumor growth was investigated by administration of melatonin, by pinealectomy or by varying the nycthemeral cycle of lighting. In the case of mammary tumors induced in female Sprague-Dawley rats by per os administration of 7.12 DMBA [dimethylbenz(a)anthracene], 2 important observations were made: the carcinogen alters the levels of pituitary serotonin, particularly at the level of the intermediary lobe, and melatonin seems to play a role in restricting tumor development. Neuro-hormonal balances, implicated in pineal-hypothalamo-pituitary hormonal regulation, play a role in tumor induction and tumor growth of mammary tumors in female rats, probably by modifying peripheral hormone secretion. The stress induced by modification of a nycthemeral cycle can, under certain experimental conditions, modify tumor response and development.